ArticleInternational ophthalmology2025
Corneal epithelial thickness in pseudoexfoliation syndrome: an anterior segment optical coherence tomography study.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to characterize corneal epithelial thickness profiles in pseudoexfoliation syndrome (PXS) patients using AS-OCT and to investigate its correlation with intraocular pressure (IOP).
methodsIn this prospective, cross-sectional study, 27 PXS patients and 26 controls underwent a comprehensive ophthalmologic examination. Corneal epithelial and total thickness were measured in central, 0-2 mm, 2-5 mm, and 5-7 mm zones using Carl Zeiss Cirrus 5000 HD-OCT. Statistical comparisons and correlations were performed.
resultsMean IOP was significantly higher in PXS patients (17.8 ± 6.9 mmHg) versus controls (14.0 ± 3.8 mmHg; p = 0.01). Central corneal thickness (CCT) was also significantly greater in PXS eyes (536.33 ± 33.62 µm) compared to controls (515.19 ± 30.16 µm; p = 0.02), with similar significant differences across all pachymetry zones. Stromal plus endothelial thickness was significantly higher in PXS centrally (p = 0.04), in the 0-2 mm (p = 0.03) and 5-7 mm (p = 0.02) zones, but this difference was non-significant in the 2-5 mm zone (p = 0.09). Crucially, epithelial thickness measurements across all zones showed no significant differences between groups (all p > 0.05). Similarly, epithelial thickness ratios to total corneal and stromal plus endothelial thickness remained unchanged (all p ≥ 0.05). While IOP was significantly positively correlated with total corneal thickness in both groups, no significant correlation was found between IOP and epithelial thickness (all p > 0.05).
conclusionDespite increased overall corneal thickness and IOP, corneal epithelial thickness profiles in PXS remained stable. Our results suggest that the PXS may primarily affect the deeper layers (stroma and endothelium) and that the epithelial layer maintains structural integrity. This is clinically relevant, as a stable epithelium may help differentiate PXS-related keratopathy from other anterior segment disorders and may guide clinicians to focus on the underlying stromal and endothelial health for diagnosis and surgical planning.
Indexed as
Identifiers
41400722What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.