SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Combined exercise training to improve gait in older stroke patients: a systematic review and network meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Early versus late anticoagulation on outcomes in large hemispheric infarction: a propensity score-matched analysis.Journal of neurology · 2026Article
- Clinical insights on "characteristics and impacts of large artery atherosclerosis (LAA) versus cardioembolism (CE) subtypes in large hemispheric infarction (LHI) of the middle cerebral artery (MCA)".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
objectiveThis study aimed to evaluate the effects of different combined exercise modalities on gait function and related outcomes in middle-aged and older adults with stroke using a network meta-analysis.
methodsThis review was conducted in accordance with PRISMA guidelines and prospectively registered in PROSPERO (CRD42024558927). Five databases (Web of Science, PubMed, Cochrane Library, Embase, and SPORTDiscus) were systematically searched up to April 1 2025. Additional studies published between 2020 and 2024 were identified through manual reference screening. The search strategy incorporated MeSH terms and followed the PICO framework.
resultsThe network meta-analysis revealed modality-specific benefits across outcome domains. Electrical nerve stimulation combined with gait training was most effective for improving postural control (SMD = 1.45 [0.21, 2.69]). Integrated aerobic training with motor control training produced the greatest improvements in gait parameters (SMD = 1.66 [0.63, 2.68]). Functional rehabilitation combined with motor control training yielded the best outcomes in functional mobility (SMD = 0.99 [0.57, 1.41]). Functional electrical stimulation combined with motor control training demonstrated the highest efficacy in enhancing standing and walking ability (MD = 6.63 [1.66, 11.60]).
conclusionsCombined exercise modalities outperform single modality interventions in improving gait related outcomes in patients with stroke. Tailored exercise prescriptions based on individual characteristics including age, stroke duration, intervention type, and training period are recommended to maximize rehabilitation efficacy.
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