Evidence map›Paper›PMID 41400466›Full record

ArticleeLife2025

Endoscopic liquid biopsies of gastric fluid in a large human patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer.

Francine C Cadoná, Thais F Bartelli, Adriane G Pelosof, Claudia Z Sztokfisz, Adriana P Bueno, Luana Batista do Carmo Dos Santos, Gabriela P Branco, Gabriel Oliveira Dos Santos, Warley A Nunes, Fernanda A Pintor and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Francine C CadonáLaboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil.
Thais F BartelliLaboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil.
Adriane G PelosofEndoscopy Section, A. C. Camargo Cancer Center, São Paulo, Brazil.
Claudia Z SztokfiszEndoscopy Section, A. C. Camargo Cancer Center, São Paulo, Brazil.
Adriana P BuenoDepartment of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Luana Batista do Carmo Dos SantosLaboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil.
Gabriela P BrancoLaboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil.
Gabriel Oliveira Dos SantosDepartment of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Warley A NunesDepartment of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Fernanda A PintorResearch Support Center, A. C. Camargo Cancer Center, São Paulo, Brazil.
Laís Lie Senda de AbrantesResearch Support Center, A. C. Camargo Cancer Center, São Paulo, Brazil.
Alexandre DefelicibusLaboratory of Computational Biology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Luiz Gonzaga Vaz CoelhoPostgraduation Program in Applied of Sciences of Adult Health & Alpha Gatroenterology Institute, Hospital das Clínicas, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Marcis LejaUniversity of Latvia, Institute of Clinical and Preventive Medicine and Center for Gastric Diseases GASTRO, Riga, Latvia.
Haejin InRutgers Cancer Institute, New Brunswick, New Brunswick, United States.
Sharon LiRutgers Cancer Institute, Newark, United States.
Howard HochsterRutgers Cancer Institute, New Brunswick, New Brunswick, United States.
Felipe J F CoimbraDepartment of Abdominal Surgery, A. C. Camargo Cancer Center, São Paulo, Brazil.
Rodrigo DrummondLaboratory of Computational Biology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Israel Tojal Da SilvaLaboratory of Computational Biology, A. C. Camargo Cancer Center, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4687-1499
Ravi J ChokshiRutgers Cancer Institute, Newark, United States.
Renata PasqualiniRutgers Cancer Institute, Newark, United States.
Wadih ArapRutgers Cancer Institute, Newark, United States.
Diana N NunesLaboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil.
Emmanuel Dias-NetoLaboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5670-8559

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/26897-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/02972-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/14267-2Levy-Longenbaugh Donor-Advised FundMinistério da Saúde PRONON/DECITMinistério da Saúde SIPAR 2500.035-167/2015-23
6 · The paper itself

Abstract

Gastric cancer remains a diagnostic and therapeutic challenge worldwide. Improved prognostic biomarkers could aid treatment planning across surgical, neoadjuvant, and adjuvant settings. We evaluated a novel liquid-biopsy approach integrated with esophagogastroduodenoscopy (EGD) by analyzing gastric fluid DNA (gfDNA) from a large cohort (n=1056) to assess its diagnostic utility and prognostic value in gastric cancer. In this exploratory study, gfDNA concentration was measured in patients with normal gastric mucosa, peptic diseases, preneoplastic conditions, or cancer. Variables included sex, gastric fluid pH, proton-pump inhibitor use, tumor subtype, stage, and outcomes. gfDNA levels were significantly higher in gastric cancer than in all comparison groups (mean 26.86 ng/µL; 95% CI 20.05-33.79; p=3.61 × 10e

Indexed as

Biomarkers, TumorDNA, NeoplasmStomach NeoplasmsAdultAgedAged, 80 and overCohort StudiesFemaleHumansLiquid BiopsyMaleMiddle AgedPrognosisBiomarkers, TumorDNA, Neoplasmcancer biologyDNA levelsgastric cancergastric fluidgastric fluidshumanliquid biopsyprognosis

Identifiers

PMID41400466
PMCPMC12707811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.