Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma.

Yang Liu, Xu Yan, Yibo Zhang, Zhenfu Gao, Fengrui Nan, Siyu Shi, Jingyun Chen, Lingyu Li

Abstract read

In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang LiuCancer Institute, The First Hospital of Jilin University, Changchun, China.ORCID https://orcid.org/0000-0001-7968-3403

Xu YanPathology Department, The First Hospital of Jilin University, Changchun, China.

Yibo ZhangClinical Laboratory, The First Hospital of Jilin University, Changchun, China.

Zhenfu GaoCancer Institute, The First Hospital of Jilin University, Changchun, China.

Fengrui NanCancer Institute, The First Hospital of Jilin University, Changchun, China.

Siyu ShiCancer Institute, The First Hospital of Jilin University, Changchun, China.

Jingyun ChenCancer Institute, The First Hospital of Jilin University, Changchun, China.

Lingyu LiCancer Institute, The First Hospital of Jilin University, Changchun, China.ORCID https://orcid.org/0000-0001-9920-6508

Funding

National Natural Science Foundation of China 82172690National Natural Science Foundation of China 82472799

6 · The paper itself

Abstract

Human pheochromocytomas and paragangliomas (PPGLs) exhibit substantial molecular and immune heterogeneity, complicating risk assessment and treatment. Here, we define three distinct tumor transcriptional subtypes (C1, C2, and C3) in a clinically annotated cohort of PPGL patients through integrative transcriptomic and immunogenomic profiling. C1 is characterized by hypoxia-driven pathways and an immunosuppressive microenvironment, correlating with poor prognosis. C2 exhibits a highly inflamed immune landscape with robust CD8

Indexed as

Adrenal Gland NeoplasmsNeoplasm Recurrence, LocalParagangliomaPheochromocytomaTumor MicroenvironmentBiomarkers, TumorFemaleHumansMaleMiddle AgedNeoplasm MetastasisPrognosisTranscriptomeBiomarkers, Tumorcancer biologyhumanimmune infiltrationmouseparagangliomaspheochromocytomasprognosis assessmenttranscriptional subtypes

Identifiers

PMID41400463

DOI10.7554/eLife.107108

PMCPMC12707812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.