Evidence map›Paper›PMID 41400434›Full record

ArticleAnnals of the New York Academy of Sciences2026

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na

Tessa A Groeneweg, Erdene Baigal, Anny Leung, Gert-Jan Kremers, Marcel J C Bijvelds

Abstract read
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In one paragraph

Article in Annals of the New York Academy of Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tessa A GroenewegDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Erdene BaigalDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Anny LeungDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Gert-Jan KremersErasmus Optical Imaging Center, Department of Pathology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Marcel J C BijveldsDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Krisanaklan (KK) is a traditional herbal remedy used to treat an array of gastrointestinal complaints, including infectious, secretory diarrhea (SD). We assessed the effect of KK on anion and fluid secretion across intestinal epithelia, and delineated its mode of action. KK inhibited cholera toxin/cAMP-dependent anion secretion across intestinal epithelial monolayers and native intestinal epithelium ex vivo. Similarly, KK reduced cAMP-dependent fluid secretion in intestinal organoids. KK inhibited Na

Indexed as

Intestinal MucosaPlant ExtractsPotassium ChannelsSodium-Potassium-Exchanging ATPaseAnimalsAnionsCaco-2 CellsHumansIon TransportSwineAnionsPlant ExtractsPotassium ChannelsSodium-Potassium-Exchanging ATPasecardiotonic steroidsCFTRcholeraNa+/K+‐ATPaseoral rehydration therapyouabainsecretory diarrhea

Identifiers

PMID41400434
PMCPMC12917929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.