Evidence map›Paper›PMID 41400349›Full record

ArticlemBio2026

The

Megan R O'Malley, Hailey N Dearing, Xuhui Zheng, Alyssa N Kretschmer, Timothy H-S Cho, Tracy L Raivio, Matthew R Parsek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. TheApplied and environmental microbiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan R O'MalleyDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0009-0002-7985-3411
Hailey N DearingDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Xuhui ZhengDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3989-7236
Alyssa N KretschmerDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Timothy H-S ChoDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-4066-1666
Tracy L RaivioDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-4450-1352
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2932-7966

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
Cooperation and antagonism in polymicrobial infectionR01AI186380 · NIAID · OHIO STATE UNIVERSITY · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2024 to 2026
$2.2M
Molecular determinants and functions of bacterial polysaccharide cellular localizationR01AI183692 · NIAID · UNIVERSITY OF WASHINGTON · PI Patricia Lynne Howell, MATTHEW R. PARSEK · 2025 to 2026
$1.5M
NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI183692NIAID NIH HHS R01 AI186380
6 · The paper itself

Abstract

Bacteria surveil their cell envelope through a network of envelope stress response systems (ESRs). Beyond regulation of envelope maintenance, ESRs influence expression of a range of virulence traits among pathogenic bacteria. The Cpx two-component system, a conserved ESR, responds to envelope stress generated by bacterial contact with a solid surface. This feature is particularly interesting in the context of bacterial biofilm formation, a key virulence trait of the opportunistic pathogen IMPORTANCE:

Indexed as

Bacterial ProteinsCell MembraneCyclic GMPPseudomonas aeruginosaStress, PhysiologicalBiofilmsGene Expression Regulation, BacterialSignal TransductionBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPbiofilmscell envelopepathogenesisPseudomonas aeruginosastress responsetwo-component regulatory systems

Identifiers

PMID41400349
PMCPMC12802237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.