Evidence map›Paper›PMID 41400119›Full record

ArticleGlia2026

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes.

S Basak, A M Colafrancesco, R D Hernandez, X Wei, L J McMeekin, D Dang, M Simmons, J L Browning, K Noel, F Zhou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ModelingbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

S BasakSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0009-0006-3034-5829
A M ColafrancescoDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-5491-1630
R D HernandezSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0001-9403-652X
X WeiSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0009-0007-8323-4660
L J McMeekinDepartment of Neuroscience, Southern Research, Birmingham, Alabama, USA.ORCID 0000-0002-2415-3947
D DangDepartment of Human Genetics, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-8833-0167
M SimmonsDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0009-0001-6101-8082
J L BrowningSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0002-3102-0667
K NoelSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0009-0001-3006-1897
F ZhouDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0009-0008-9174-123X
F E LundDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-3083-1246
J S SaadDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-9503-6484
S G WatsenSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0009-0001-4189-1052
A M PickrellSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0002-8470-6056
R M CowellDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-5814-9412
M L OlsenSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0003-1394-664X

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Glial Involvement in REDOX Homeostasis in the Substantia NigraR01NS124037 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI COWELL, RITA MARIE · 2021 to 2025
$2.8M
UAB Training Program In NeuroscienceT32NS095775 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2017 to 2026
$1.6M
MicroCal Auto-iTC200; automated high sensitivity isothermal titration calorimetryS10RR026478 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROUILLETTE, CHRISTIE G. · 2010 to 2010
$250k
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR026478NIH HHS 1S10RR026478NIH HHS R01NS124037NIH HHS T32NS09.5775NINDS NIH HHS R01 NS124037NINDS NIH HHS T32 NS095775
6 · The paper itself

Abstract

CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis. CD38 dysregulation and gene variation is reported in neurodegenerative conditions such as Parkinson's disease (PD) and Alzheimer's disease (AD), highlighting the need to better understand CD38 biology within the brain. Here, we demonstrate enrichment of Cd38 in midbrain astrocytes and describe how CD38 deficiency influences brain metabolism, astrocytic gene expression, and bioenergetics. We demonstrate increased NAD content, decreased NAM content, and increased NAD/NAM in the midbrain and striatum of CD38-deficient (Cd38

Indexed as

ADP-ribosyl Cyclase 1AstrocytesHomeostasisMembrane GlycoproteinsAnimalsBrainMaleMesencephalonMiceMice, Inbred C57BLMice, KnockoutNADADP-ribosyl Cyclase 1Cd38 protein, mouseMembrane GlycoproteinsNADagingastrocytebrain metabolismmitochondrianeurodegenerationRNA‐sequencing

Identifiers

PMID41400119
PMCPMC12706826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.