ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Preserved cognitive-functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Health status characteristics and aging determinants of centenarians in Colombia: a real-life expanded cohort profile description.BMC geriatrics · 2026Article
- Preserved cognitive-functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionResearch on dementia in centenarians is scarce. This study assesses the 2024 Lancet Commission risk factors for dementia in Colombian centenarians.
methodsThe Clinical Dementia Rating-Sum of Boxes (CDR-SB), Mini-Mental State Examination, and Barthel Index were evaluated in Colombian centenarians. A preserved cognitive-functional phenotype (PCFP), defined by a CDR-SB <2 and a Barthel index ≥60, was utilized to signify the absence of dementia based on cognitive screening instruments. Associations with age-related clinical variables were assessed through multivariate analyses.
resultsAmong 160 centenarians, 63.7% did not meet the PCFP criteria and were classified as having dementia. Frailty, alcohol intake, and depression were linked to dementia, while physical performance, nutritional status, and quality of life were associated with PCFP. Physical activity, education, obesity, hypertension, diabetes, and smoking showed no significant associations. DISCUSSION: Traditional dementia risk factors were not universally confirmed in centenarians, underscoring the need for prevention strategies tailored to specific settings. HIGHLIGHTS: Dementia risk factors act differently in Colombian centenarians. Frailty and malnutrition strongly linked to dementia in centenarians. Preserved cognitive-functional phenotype identified in 36% of centenarians. Quality of life and physical performance protect against cognitive decline. Classical risk factors (education, hypertension, diabetes) showed no effect.
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