ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Effect of Alginate Coatings on Hydroxyapatite/β-Tricalcium Phosphate Scaffold Behavior.Journal of functional biomaterials · 2026Article
- Mechanisms of active wetting and fluidification in epithelial cell collectives.Nature materials · 2026Article
- Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment.Frontiers in bioengineering and biotechnology · 2026Review
- Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Pioneering a novel integrated photonic platform, Brillouin-Raman Microspectroscopy on-a-Chip is presented, which enables real-time, high resolution analysis of mechano-chemical dynamics in complex 3D biological systems under controlled deformation. This contact-free, all-optical method seamlessly combines Brillouin and Raman microscopy within microfluidic devices, providing a unique correlative approach to overcome current limitations in probing cellular mechanics and biochemical responses in live multicellular models. This innovative platform, when applied to breast tumor spheroids, revealed that rapid, cyclical mechanical deformations, mimicking in vivo stresses, profoundly impacts tumor physiology. These findings demonstrate that controlled deformations trigger rapid nuclear shape changes and robust transcriptional reprogramming, marked by a significant (48-fold) upregulation of the early stress response regulator ATF3. These responses are accompanied by global spheroid stiffening, as precisely quantified by Brillouin spectroscopy. Remarkably, repeated deformation imprints a form of mechanical memory in these collective systems, which culminates in enhanced collagen invasion over 24 h. The label-free methodology sets a new benchmark in biophotonics, unlocking a new class of experiments to probe and modulate physiological and pathological processes with transformative potential for cancer research, broader mechanobiology, and the study of mechanical memory in organoids and other complex 3D models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.