Evidence map›Paper›PMID 41399797›Full record

ArticleChinese herbal medicines2025

Microbiota basis of antidepressant effects of Zhi-zi-chi Decoction:

Jing He, Zixin Zhao, Ying Ye, Yujia Zhai, Dexun Yu, Fangyuan Gao, Jianlin Wu, Jun Wen, Tingting Zhou

Abstract read
In one paragraph

Article in Chinese herbal medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Frontiers in microbiology · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing HeSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Zixin ZhaoSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Ying YeSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Yujia ZhaiNaval Medical Center, Second Military Medical University, Shanghai 200433, China.
Dexun YuSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Fangyuan GaoDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.
Jianlin WuState key laboratory of mechanism and quality of Chinese medicine, Macau University of Science and Technology, Taipa, Macau SAR, 999078, China.
Jun WenSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Tingting ZhouSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Zhi-zi-chi Decoction (ZZCD) is a classical antidepressant traditional Chinese medicine (TCM) formula. However, the microbiological basis of its antidepressant effects remains unclear. The objective of this study was to investigate the microbial basis of ZZCD. Methods: The bacteria that exhibit enhanced growth in ZZCD extracts were identified through Results: ZZCD was able to promote the growth of Conclusion:

Indexed as

antidepressant effectsLactobacillus rhamnosusmetabolitesmicrobial basesZhi-zi-chi Decoction

Identifiers

PMID41399797
PMCPMC12702427

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.