Evidence map›Paper›PMID 41399681›Full record

ArticleVaccine: X2025

Rhamnose polysaccharide-decorated outer membrane vesicles as a vaccine candidate targeting Group A Streptococcus from

Sowmya Ajay Castro, Sarah Thomson, Helen Alexandra Shaw, Azul Zorzoli, Benjamin H Meyer, Mark Reglinski, Mark McNeil, Helge C Dorfmueller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sowmya Ajay CastroMolecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Sarah ThomsonBiological Services, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Helen Alexandra ShawVaccine Division, Scientific Research & Innovation Group, MHRA, Potters Bar, United Kingdom.
Azul ZorzoliMolecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Benjamin H MeyerMolecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Mark ReglinskiMolecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Mark McNeilMolecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Helge C DorfmuellerMolecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

Funding

Wellcome Trust 105606Wellcome Trust 221589
6 · The paper itself

Abstract

Group A Streptococcus (Strep A) cause a wide range of human-exclusive infections, annually killing more than 500,000 people. Antibiotic resistance incidence of invasive Strep A tripled in the past decade and emphasises the need to develop a universal Strep A vaccine. In this study, we developed recombinant rhamnose polysaccharides (RhaPS), a validated universal Strep A vaccine candidate, presented on

Indexed as

Group a carbohydrateGroup a StreptococcusM proteinOuter membrane vesiclesRhamnoseStreptococcus pyogenesVaccine

Identifiers

PMID41399681
PMCPMC7618470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.