Evidence map›Paper›PMID 41399670›Full record

ReviewJAAD international2026

Association between hair dye use and human cancers: A systematic review.

Rachel K Greene, Jalal Maghfour, Cristina Nguyen, Gabrielle Baker, Natasha Atanaskova Mesinkovska

Abstract readReview
In one paragraph

Review in JAAD international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rachel K GreeneDepartment of Dermatology, University of California Irvine, Irvine, California.
Jalal MaghfourDepartment of Dermatology, Henry Ford Health, Detroit, Michigan.
Cristina NguyenDepartment of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California.
Gabrielle BakerSchool of Medicine, University of California, Irvine School of Medicine, Irvine, California.
Natasha Atanaskova MesinkovskaDepartment of Dermatology, University of California Irvine, Irvine, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The global hair color market is valued over 23 billion dollars with over 2 billion in sales in the United States. Permanent hair dye accounts for approximately 80% of hair dye products on the market. Objective: To systematically review the association between hair dye use and cancer risk and identify vulnerable populations. Methods: A systematic search of PubMed and MEDLINE from January 1964 to March 2025 was conducted. Articles were reviewed independently by 3 assessors. Results: The review included 96 articles including 2 on both adults and children, and 5 on maternal exposure and pediatric cancer risk. Some studies suggested potential associations between hair dye use and cancer risk. Trends include increased risk of estrogen receptor + breast cancer among African American women and elevated bladder cancer in both genders. risk in frequent users. Individuals with slow acetylator N-acetyltransferase 2 genotypes or Limitations: Limitations include elements of study design, study populations, and confounders. Conclusion: There is evidence to suggest possible increased cancer risks for frequent, long-term hair dye use in specific populations.

Indexed as

bladder cancerbreast cancercancerhair dyesleukemianeoplasmnon-Hodgkin’s lymphomaparaphenylenediamine (PPD)

Identifiers

PMID41399670
PMCPMC12702374

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.