ReviewBiochemia medica2026
Claudins proteins in brain tumors: expression patterns and therapeutic target.
Review in Biochemia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Circulating PDIA4, MMP-2, MMP-9, and Claudin-2 in Vitamin D-Deficient Patients with Brain Tumors: An Exploratory Clinical Pilot Study.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tight junctions (TJs) are essential for preserving cell polarity and controlling permeability. It has been disclosed that TJ proteins, especially specific claudins (CLDNs), are linked to inflammation and contribute to the emergence of diverse cancers, including brain malignancies. Aggressive gliomas, including glioblastoma multiforme (GBM), remain among the most common and deadly central nervous system (CNS) tumors worldwide, despite considerable advances in diagnostic and therapeutic approaches. These types of tumors are characterized by high rates of recurrence and metastasis, resulting in poor outcomes and prognosis. The pathophysiology of brain cancer is closely linked to CLDNs, as these specific proteins play critical roles in tumor cell proliferation, invasion, and disruption of the blood-brain barrier (BBB). Some studies reported the potential role of CLDNs in glioma progression and other neurological disorders. The purpose of this review is to highlight the significance of CLDNs in CNS tumors, especially their participation in the formation of malignant gliomas. Additionally, the diagnostic and prognostic importance of selected CLDNs has been assessed. Selected CLDNs, such as CLDN3 and CLDN4 promote GBM growth, proliferation and migration. Moreover, overexpression of CLDN3 support progression and metastasis of these malignancies, while reduced expression of CLDN1 and CLDN5 is observed in advanced gliomas. Presented results suggest that CLDNs may serve as biomarkers for diagnosis and prognosis as well as therapeutic targets in CNS tumors. Further investigation is essential to clarify their clinical relevance and therapeutic potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.