ArticleIJID regions2025
Characteristics and mortality factors of severe malaria in children and teenager aged from 5 to 15 years in Thiès region, Senegal.
Article in IJID regions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Severe malaria remains a major cause of pediatric morbidity and mortality. This study assessed the characteristics and mortality of severe malaria in children and adolescents in Thiès, Senegal. Methods: Retrospective multicenter study in four multicenter referral hospitals (July 2019-June 2024), including children aged 5 to 15 hospitalized for confirmed severe malaria, defined by a positive rapid diagnostic test and/or thick blood smear, along with at least one World Health Organization (WHO) criterion (2015). Analyses used R software. Results: We recorded 109 cases. Mean age 9.56 ± 2.87 years (5-15); sex ratio 1.95. Most patients (60%) originated from rural areas, with admissions mainly in the post-rainy season, especially in October (36.7%) and November (22.9%). Frequent signs included prostration (27%), convulsions (21.10%), coma (17.43%), alongside severe anemia (33%) and thrombocytopenia (61.62%). All patients tested positive on rapid diagnostic tests; among the 46 thick blood smear tests, 97.8% were positive. Injectable artesunate was first-line, followed by artemisinin-based combination therapy (82%); antibiotics were used in 50.46%. Outcomes were favorable in 90%, with 5.5% sequelae and 4.5% mortality. Mortality was significantly associated with respiratory distress and ≥2 WHO severity criteria. Conclusions: The associated lethality and mortality are considerable, with notable neurological and functional sequelae observed.
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