Evidence map›Paper›PMID 41399606›Full record

ArticleStructural heart : the journal of the Heart Team2025

Impact of Basal Septal Bulge on Conduction Disturbance After Transcatheter Aortic Valve Replacement Using ACURATE neo/neo2.

Yoichi Sugiyama, Noriaki Moriyama, Hirokazu Miyashita, Sebastian Dahlbacka, Tommi Vähäsilta, Tiina Vainikka, Mikko Jalanko, Juho Viikilä, Mika Laine

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Article in Structural heart : the journal of the Heart Team, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yoichi SugiyamaDepartment of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura City, Kanagawa, Japan.
Noriaki MoriyamaDepartment of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura City, Kanagawa, Japan.
Hirokazu MiyashitaDepartment of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura City, Kanagawa, Japan.
Sebastian DahlbackaDepartment of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
Tommi VähäsiltaDepartment of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
Tiina VainikkaDepartment of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
Mikko JalankoDepartment of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
Juho ViikiläDepartment of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
Mika LaineDepartment of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: New-onset conduction disturbance (CD) is a common complication of transcatheter aortic valve replacement (TAVR). Recently, basal septal bulge (BSB) has been reported as a predictor of CD. However, the impact of BSB on CD using ACURATE neo/neo2 remains unclear. We hypothesized that the left bundle branch could be damaged in patients with large BSB even by low radial force. This study investigated the predictors of CD after TAVR using ACURATE neo/neo2 and the impact of BSB on CD. Methods: We retrospectively analyzed 518 patients who underwent TAVR with ACURATE neo/neo2 in a single center. New-onset CD was defined as 30-day new permanent pacemaker implantation or new left bundle branch block lasting until discharge. The endpoints were the predictors of CD and the effect of BSB. Results: The incidence of CD was 11.0%. Multivariate analysis showed that complete right bundle branch block (odds ratio [OR]: 3.45; 95% CI: 1.63-7.30), membranous septum length <2 mm (OR: 2.14; 95% CI: 1.19-3.85), and BSB ≥3 mm (OR: 2.17; 95% CI: 1.22-3.86) were independent baseline predictors of CD. Postdilatation was the sole procedural predictor (OR: 2.28; 95% CI: 1.03-5.02). The risk of CD could be stratified according to the number of baseline predictors in patients with BSB ≥3 mm (0: 9.5%, 1: 26.1%, 2: 66.7%, Conclusions: BSB was significantly associated with CD in ACURATE neo/neo2, and CD risk could be stratified using baseline factors in patients with large BSB. These findings might be beneficial for periprocedural management and TAVR strategy.

Indexed as

Aortic stenosisBasal septal bulgeConduction disturbanceSelf-expanding valveTranscatheter aortic valve replacement

Identifiers

PMID41399606
PMCPMC12702448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.