ReviewCureus2025
Therapeutic Dilemmas in the Management of Stroke Among Patients With Infective Endocarditis (IE): A Literature Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis (IE) is an infection of the endocardial lining of the heart, with high morbidity and mortality. Neurological complications, mainly stroke, represent the most frequent and devastating extracardiac manifestations. Despite continued advancements in diagnostics and management, the optimal strategies and guidelines to prevent and treat IE-associated stroke remain controversial and scarce. We conducted a detailed narrative review of recent literature focusing on the epidemiology, risk factors, pathophysiology, diagnostic approaches, and therapeutic strategies for stroke in the context of IE. Evidence was drawn from multinational cohort studies, systematic reviews, guideline statements, and recent updates in imaging, surgical practices, and guidelines. Stroke leads to complications in approximately 15%-20% of IE cases, with regional variation linked to healthcare-associated infections, intravenous drug use, and rheumatic or congenital heart disease. Risk factors include
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