Evidence map›Paper›PMID 41399395›Full record

ReviewEye and brain2025

A Narrative Review of the Association Between Cataracts and Dementia.

Ha-Neul Yu, Gui-Shuang Ying

Abstract readReview
In one paragraph

Review in Eye and brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ha-Neul YuPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Gui-Shuang YingCenter for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5752-1355

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
NEI NIH HHS P30 EY001583
6 · The paper itself

Abstract

Dementia and cataract are two of the most prevalent conditions in older adults, together representing a substantial global health burden. Increasing evidence suggests a potential link between cataract and dementia, and this narrative review synthesizes current epidemiological and mechanistic evidence on their association. Recent cohort and case-control studies report a modestly increased risk of dementia in individuals with cataracts, though inconsistencies persist across populations. Mechanistic insights highlight roles for visual impairment and protein aggregation in this association. Importantly, cataract surgery shows a robust, protective effect against incident dementia, potentially via restoration of sensory input and enhanced cognitive engagement. Future studies may examine longitudinal, multi-ethnic cohorts that integrate genetic, imaging, and molecular data to investigate causality and the underlying biological mechanisms. In summary, our narrative review shows that cataract and dementia may be linked through multifactorial pathways, and maintaining visual health, particularly through timely cataract surgery, represents a potentially modifiable factor in dementia prevention strategies.

Indexed as

cataractcataract surgerydementia

Identifiers

PMID41399395
PMCPMC12702263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.