ReviewInternational journal of medical sciences2026
Role of Circular RNAs in Liver Diseases.
Review in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- RNA-binding proteins in aging and age-related diseases: roles, mechanisms, and a large language model analysis.Biogerontology · 2026Review
- CircRNAs in hepatic lipid metabolism: regulatory mechanisms and clinical implications.Frontiers in genetics · 2026Review
- Target, silence, replace: a review on RNA-based drugs in modern medicine.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a subclass of noncoding RNAs characterized by their closed-loop structure without terminal 3' or 5' ends. Studies have shown that circRNAs play pivotal roles in the regulation of various cellular processes. These molecules function as microRNA (miRNA) sponges, interact with RNA-binding proteins, and modulate gene transcription. CircRNAs are vital for regulating liver homeostasis, and dysregulation of their expression is correlated with liver diseases such as hepatic fibrosis, steatosis, inflammation, and liver cancer. Elucidating the functional significance of circRNAs in liver diseases is crucial, as this knowledge may facilitate the identification of novel diagnostic biomarkers and therapeutic targets for conditions that contribute significantly to global morbidity and mortality. This review aimed to highlight current research underscoring the functional roles of circRNAs in the molecular pathogenesis and progression of liver diseases, including hepatocellular carcinoma, nonalcoholic fatty liver disease, and liver fibrosis. To provide an updated and comprehensive overview, a literature search was conducted across major scientific databases. This review reveals that circRNAs perform multifaceted functions in liver homeostasis and disease by regulating gene expression through miRNA sponging, interacting with signaling pathways, and influencing cellular processes, including vascularization, metastasis, the cell cycle, apoptosis, cellular stress, metabolic activity, inflammatory responses, and cellular senescence. Despite their pivotal involvement in liver diseases, translating circRNA-based research into clinical practice remains challenging. In conclusion, circRNAs represent an emerging frontier in liver disease research, offering considerable promise for future clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.