Evidence map›Paper›PMID 41399343›Full record

ArticleGastro hep advances2025

Patient-Reported Outcome Scores Are Comparable in Multiregional Versus Uniregional Eosinophilic Esophagitis.

Margaret H Collins, Zhaoxing Pan, Guang-Yu Yang, Nicoleta C Arva, Maria A Pletneva, Lisa J Martin, Seema Aceves, Mirna Chehade, Evan S Dellon, Jonathan M Spergel and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Margaret H CollinsDivision of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
Zhaoxing PanDepartment of Biostatistics, University of Colorado School of Medicine, Aurora, Colorado.
Guang-Yu YangVirginia Commonwealth University, Richmond, Virginia.
Nicoleta C ArvaDepartment of Pathology, Nationwide Children's Hospital, Columbus, Ohio.
Maria A PletnevaDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, Utah.
Lisa J MartinDivision of Human Genetics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Seema AcevesDivision of Allergy and Immunology, University of California, San Diego, Rady Children's Hospital, San Diego, California.
Mirna ChehadeMount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York.
Evan S DellonDivision of Gastroenterology and Hepatology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina.
Jonathan M SpergelDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.
Paul Menard-KatcherDivision of Gastroenterology, Hepatology and Nutrition, University of Colorado, Aurora, Colorado.
Kathryn A PetersonDivision of Gastroenterology, Hepatology, and Nutrition, University of Utah, Salt Lake City, Utah.
Paneez KhouryNational Institutes of Allergy and Infectious Disease, NIH, Bethesda, Maryland.
Nirmala GonsalvesDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Sandeep K GuptaDivision of Gastroenterology, Hepatology and Nutrition, University of Alabama at Birmingham, Birmingham, Alabama.
Carla M DavisDepartment of Pediatrics and Child Health, Howard University, Washington, District of Columbia.
Gary W FalkDivision of Gastroenterology, Perelman School of Medicine at University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Joshua B WechslerDivision of Gastroenterology, Hepatology and Nutrition, Departments of Pediatrics and Allergy, Lurie Children's Hospital, Northwestern Feinberg School of Medicine, Chicago, Illinois.
Robert PesekDepartment of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas.
Girish HiremathDepartment of Pediatrics, Vanderbilt University, Vanderbilt University Medical Center, Nashville, Tennessee.
John LeungDepartment of Allergy, Asthma and Immunology, Department of Gastroenterology, Boston Food Allergy Center, Boston, Massachusetts.
David A KatzkaDepartment of Medicine, Columbia University Irving Medical Center, New York, New York.
Glenn T FurutaDigestive Health Institute, Children's Hospital Colorado, Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, Colorado.
Marc E RothenbergDivision of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Funding

The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Michal Kouril · 2019 to 2026
$51.2M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Nirmala P Gonsalves · 2014 to 2026
$18.5M
NCATS NIH HHS U2C TR002818NIAID NIH HHS U54 AI117804NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Background and Aims: Eosinophilic esophagitis (EoE) clinical trials often require multiregional esophageal inflammation. To determine if patient-reported outcomes (PROs) worsen with multiregional eosinophil inflammation (≥15 eosinophils/high power field), we compared outcomes scores when multiple (proximal/mid/distal) esophageal regions, versus one, were inflamed. Methods: The Consortium of Eosinophilic Gastrointestinal Disorders Researchers database was searched for peak eosinophil counts (PECs), eosinophilic esophagitis histology scoring system scores, and PRO scores (eosinophilic esophagitis activity index; Pediatric Eosinophilic Esophagitis Symptom Score; EoE quality of life; Pediatric Quality of Life Eosinophilic Esophagitis modulev3.0) in submissions from one or more regions. Analyses were performed with unadjusted or adjusted (adults: age, sex, dilation within 1 year; children: age, sex) data, using Wilcoxon rank sum and T test, and least squares mean, respectively. An interaction test was used for subgroup analysis. Results: Adult PEC was 60.2 ± 44.8 vs 39.5 ± 29.9 (mean ± standard deviation, Conclusion: Multiregional compared to uniregional esophageal eosinophil inflammation does not significantly impact most PRO scores, and may not be necessary for all clinical trials.

Indexed as

Clinical careClinical disease metricsDiagnosisSymptom correlationTtesting clinical trial enrollment assumptions

Identifiers

PMID41399343
PMCPMC12702438

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.