Evidence map›Paper›PMID 41399192›Full record

ArticleVeterinary ophthalmology2026

Ultraviolet C (UV-C) Light Therapy Inhibits Pathogens Associated With Equine Keratomycosis at Different Corneal Depths-An Ex Vivo Study.

Mona Hoerdemann, Dipak K Sahoo, Rachel A Allbaugh, Melissa A Kubai

Abstract read
In one paragraph

Article in Veterinary ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mona HoerdemannDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.ORCID https://orcid.org/0000-0002-3268-1301
Dipak K SahooDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.ORCID https://orcid.org/0000-0003-3748-3395
Rachel A AllbaughDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Melissa A KubaiDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.ORCID https://orcid.org/0000-0003-0091-2037

Funding

International Equine Ophthalmology Consortium 028567-00001Iowa State University CVM PG105121
6 · The paper itself

Abstract

objectiveTo assess if an inexpensive, commercially available ultraviolet C (UV-C) light device with a peak emission of 275 nm can inhibit equine keratomycosis-associated pathogens located at different corneal depths in an ex vivo model.

methodsA controlled, randomized experimental design. Aspergillus fumigatus and Fusarium solani isolates were inoculated in fresh bovine corneoscleral transplants, superficially or at 450 μm of stromal depth for the ulcerative keratomycosis or stromal abscess model, respectively. After a minimum of 18 h of incubation, treatment groups received 15 s of UV-C light exposure at a 10 mm distance from the corneal surface level (22.5 mJ/cm

resultsUV-C treatment resulted in statistically significantly higher MFI-PI, lower MFI-SYTO 9 and lower normalized MFI ratios (SYTO 9/[SYTO 9 + PI]) compared to controls for both isolates irrespective of corneal depth; therefore demonstrating successful fungal inactivation. In superficial location, fungal inhibition reached 88% for both isolates. At deeper corneal depth, fungal inhibition was not significantly different for F. solani (84%) but significantly less complete for A. fumigatus (60%).

conclusionsCorneal UV-C light treatment may offer therapeutic benefits for ulcerative keratomycosis and stromal abscesses in the equine species using doses expected to be safe for corneal exposure based on previously published safety data. Species-specific safety studies are required to ensure that antifungal efficacy aligns with safe clinical practice.

Indexed as

AspergillosisAspergillus fumigatusEye Infections, FungalFusariosisFusariumHorse DiseasesKeratitisUltraviolet RaysUltraviolet TherapyAnimalsCattleCorneaHorsesAspergillus fumigatusconfocal laser scanning microscopyequine keratomycosisFusarium solaniSYTO 9‐PIUV‐C therapy

Identifiers

PMID41399192
PMCPMC12963518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.