ArticleMagnetic resonance in medicine2026
Trityl OXO71 Pharmacokinetics and Distribution in Rhesus Macaques.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeElectron paramagnetic resonance oxygen imaging (EPROI) techniques have the ability to quantify the partial pressure of oxygen (pO
methodsA 92 μmol/kg OXO71 dose, equivalent to doses used in studies with other animal species, was administered as a bolus injection over a 10-min period in 3 animals. Plasma and urine were sampled over the subsequent 2 h. A second equivalent dose was then rapidly administered, animals were euthanized, and OXO71 distribution was assessed in harvested tissues by EPR imaging.
resultsPharmacokinetics of plasma OXO71 determined by EPR spectroscopy showed biphasic clearance, characterized by distinct initial and terminal half-lives of 12.4 ± 1.2 min and 67.7 ± 8.9 min, respectively. Some variability in trityl concentration was observed between organs, but appreciable concentration was found for all tissues except the brain.
conclusionNo adverse physiological effects of the infusions were observed, consistent with a low toxicity of OXO71. These findings indicate EPROI using OXO71 is safe in primates, and provide information related to the dose and time constraints for performing EPROI in other large animal species including humans.
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