Evidence map›Paper›PMID 41399007›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2026

Smartphone language and resting-state EEG indicators of self-focused attention prospectively predict major depressive disorder risk in adolescents.

Lilian Y Li, Nayoung Kim, Esha Trivedi, Sarah E Sarkas, Madeline M McGregor, Aishwarya Sritharan, Katherine Durham, Ivan Alekseichuk, Allison M Letkiewicz, Vijay A Mittal and 4 more

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lilian Y LiDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7507-3632
Nayoung KimDepartment of Psychiatry, Columbia University, New York, NY, USA.ORCID 0009-0000-0394-0741
Esha TrivediDepartment of Psychiatry, Columbia University, New York, NY, USA.
Sarah E SarkasDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.
Madeline M McGregorDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.
Aishwarya SritharanDepartment of Psychiatry, Columbia University, New York, NY, USA.
Katherine DurhamDepartment of Psychiatry, Columbia University, New York, NY, USA.
Ivan AlekseichukDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.
Allison M LetkiewiczDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.
Vijay A MittalDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.
David PagliaccioDepartment of Psychiatry, Columbia University, New York, NY, USA.ORCID 0000-0002-1214-1965
Nicholas B AllenDepartment of Psychology, University of Oregon, Eugene, OR, USA.
Randy P AuerbachDepartment of Psychiatry, Columbia University, New York, NY, USA.ORCID 0000-0003-2319-4744
Stewart A ShankmanDepartment of Psychiatry and Behavioral Sciences, Stephen M. Stahl Center for Psychiatric Neuroscience, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-8097-4483

Funding

Social Processing Deficits in Remitted Adolescent DepressionR01MH119771 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI AUERBACH, RANDY PATRICK, SHANKMAN, STEWART AARON · 2020 to 2025
$3.7M
MAPS: Mobile Assessment for the Prediction of SuicideU01MH116923 · NIMH · UNIVERSITY OF OREGON · PI ALLEN, NICHOLAS B, AUERBACH, RANDY PATRICK · 2018 to 2022
$3.6M
Motoric features of the voice as indicators of psychomotor agitation and retardation in current and remitted MDDR01MH134369 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MATTHEW A GOLDRICK, VIJAY A MITTAL · 2024 to 2026
$2.2M
Linguistic and Neural Synchrony During Co-Rumination as Interpersonal Mechanisms of Depression in Adult and Adolescent DyadsK99MH133991 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LI, LILIAN Y. · 2024 to 2025
$223k
Morgan Stanley FoundationNIMH NIH HHS K99MH133991NIMH NIH HHS R01MH119771NIMH NIH HHS R01MH134369NIMH NIH HHS U01MH116923
6 · The paper itself

Abstract

backgroundCentral to major depressive disorder (MDD) onset and maintenance is maladaptive self-focused attention, which can be reliably indexed by greater: (a) usage of first-person singular pronouns (e.g., I) in natural language and (b) alpha oscillations in resting-state EEG. Integrating these largely parallel bodies of research, the present study sought to explicate the associations between, and prospective predictive utility of, linguistic and neural indicators of self-focused attention in adolescents with remitted MDD over 12 months.

methodsAt baseline, 126 adolescents (ages 13-18) with (n = 66) and without (n = 60) remitted MDD completed resting-state EEG. Retrospective interviews determined the occurrence of major depressive episodes (MDEs) during the follow-up period. A total of ~2.3 million messages were passively acquired from adolescents' smartphones, on which the proportion of first-person singular pronouns was derived.

resultsDuring the 12 months, 29 (23.0%) participants developed an MDE (28 remitted MDD, 1 control). Cox regression showed that while greater usage of first-person singular pronouns prior to MDE increased the risk for MDE (hazard ratio [HR] = 2.02, p < .001), greater resting-state alpha power at baseline decreased the risk for MDE (HR = 0.78, p = .001). Moreover, greater alpha power predicted subsequent first-person singular pronoun usage (β = 0.17, p = .004). Mediation analysis indicated a marginal suppression effect (bootstrapped indirect effect p < .10), such that accounting for first-person singular pronoun usage amplified the association between alpha power and MDE risk.

conclusionsFindings highlight functionally distinct alpha mechanisms and provide support for smartphone-based first-person singular pronoun usage as a neurobehavioral risk factor and a potentially promising intervention target for adolescent MDD.

Indexed as

Alpha RhythmAttentionMajor Depressive DisorderSmartphoneAdolescentElectroencephalographyFemaleFollow-Up StudiesHumansMaleadolescenceDepressiondigital phenotypingEEG alpha oscillationsself‐focused attention

Identifiers

PMID41399007
PMCPMC13170627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.