ArticleBMC geriatrics2025
Evaluation of protein profile in vitreous samples of patients with naive age-related macular degeneration using proteomic approaches.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-related macular degeneration (AMD) represents one of the most common causes of permanent vision impairment in individuals over 50 years of age.
methodsThis study aims to characterize AMD using proteomic analysis to enhance diagnosis and treatment strategies. In a prospective case-control clinical trial, vitreous fluids (VF) from thirteen AMD patients were collected during surgery and analyzed by 2DE-based MALDI TOF-TOF MS/MS. PANTHER and STRING analyses were performed to investigate the biological relationships between the identified proteins and to determine relevant cellular pathways.
resultsA total of 11 proteins were differentially regulated between AMD patients and healthy controls. Among them, Apolipoprotein E was significantly up-regulated (↑3-fold), while ten proteins, including alpha-crystallin A chain (↓779-fold), beta-crystallin B2 (↓232-fold), and haptoglobin (↓15-fold), were markedly down-regulated. These quantitative differences underscore the critical role of lipid metabolism, oxidative stress response, and inflammation in AMD pathogenesis.
conclusionThe identified proteins are related to biological regulation, retinal protection, and regulation of inflammation and angiogenesis processes. The up-regulation of Apolipoprotein E highlights its involvement in lipid metabolism and inflammatory modulation, while the sharp down-regulation of crystallin family proteins suggests compromised retinal protection against oxidative stress and apoptosis. These protein alterations provide new insights into AMD pathogenesis and may serve as potential biomarkers for early diagnosis and novel therapeutic targets in managing the disease.
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