Evidence map›Paper›PMID 41398904›Full record

ArticleBMC genomics2025

Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.

Zhenhua Liu, Qiang Wang, Wenqing Wang, Jin Ding, Panpan Lv, Yue Jiang, Xuzhi Wang, Yue Liu, Chengjie Zhang, Chi Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ISFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhenhua Liu *Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Qiang Wang *Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Wenqing WangDepartment of Microbiology, Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai, China.
Jin DingDepartment of Microbiology, Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai, China.
Panpan LvDepartment of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Yue JiangResearch and Translational Laboratory of Acute Injury and Secondary Infection & Department of Emergency, Minhang Hospital, Fudan University, Shanghai, China.
Xuzhi WangDepartment of Laboratory Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Yue LiuDivision of Pathogen Testing and Analysis, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Chengjie ZhangCollege of Acupuncture-moxibustion, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Chi ZhangDepartment of Microbiology, Minhang Center for Disease Prevention and Control, Shanghai, China.
Lingfei LuoDepartment of Microbiology, Minhang Center for Disease Prevention and Control, Shanghai, China.
Yibin ZhouDepartment of Microbiology, Minhang Center for Disease Prevention and Control, Shanghai, China. yibin_zhou@hotmail.com.
Xuebin XuDivision of Pathogen Testing and Analysis, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. xuxuebin@scdc.sh.cn.
Mingliang ChenResearch and Translational Laboratory of Acute Injury and Secondary Infection & Department of Emergency, Minhang Hospital, Fudan University, Shanghai, China. cmlbright@126.com.

Funding

Fudan-Minhang Health Consortium 2024FM02National Natural Science Foundation of China 82272381
6 · The paper itself

Abstract

backgroundAs an important foodborne bacterium, non-typhoidal Salmonella (NTS) is estimated to cause approximately 215,000 deaths worldwide each year. Globally, S. Montevideo has been reported to cause several outbreaks, with low frequencies of antimicrobial resistance (AMR). In China, the information on S. Montevideo isolates was limited, especially the genomic data. This study aimed to characterize the phenotypic and genomic features of 26 S. Montevideo isolates collected in China between 2018 and 2024. During this period, 26 S. Montevideo isolates were collected from different sources in five provinces or municipalities in China. Minimum inhibitory concentrations (MICs) of nine antimicrobial agents were determined using the broth microdilution method. Isolates were sequenced on the Illumina platform to identify antimicrobial resistance genes, virulence genes, mobile genetic elements (MGEs), and phylogenetic relationships with global isolates.

resultsThe whole length of the 26 assembled genome sequences ranged from 4,612,761 bp to 5,071,299 bp. There were three sequence types (STs), among which ST-4 (61.5%, 16/26) was predominant, followed by ST-10844 (34.6%, 9/26) and ST-316 (3.8%, 1/26). A total of 21 isolates (80.8%) harbored multidrug resistance (MDR). They showed AMR phenotypes to ampicillin (76.9%, 20/26), cefotaxime (26.9%, 7/26), and ciprofloxacin (69.2%, 18/26; including three ciprofloxacin-intermediate isolates), corresponding to AMR genes and/or chromosomal point mutations of β-lactams (76.9%, 20/26) and fluoroquinolones (100%, 26/26). All ST-10844 isolates possessed MDR, with higher proportions of resistance to cefotaxime and tetracycline. The corresponding AMR genes were mainly carried by two plasmids, IncHI2 and pKPC-CAV1321. The number of virulence genes among the S. Montevideo genomes ranged from 151 to 153, with type III secretion system genes (T3SS; n = 86) predominant. The ranges of the number of prophages, Salmonella Pathogenic Islands (SPIs), plasmid replicons, and MGEs were 2-4, 8-10, 0-5, 17-30, respectively. Phylogenetic analysis showed that global S. Montevideo strains can be divided into five clades, including a novel clade, clade V. Most Chinese isolates (96.6%, 28/29) were assigned to clade II. All the ST-10,844 isolates were from mainland China and assigned to clade II, constituting a distinct cluster.

conclusionThis study is the first report to characterize S. Montevideo genomes from China. The phenotypic and genomic characteristics of Chinese S. Montevideo isolates were distinct from isolates of other countries, standing out with MDR and tending to be waterborne. A ST-10844 cluster was identified, with higher frequencies of resistance to cefotaxime and tetracycline.

Indexed as

Drug Resistance, Multiple, BacterialGenome, BacterialGenomicsSalmonellaAnti-Bacterial AgentsChinaHumansMicrobial Sensitivity TestsPhylogenySerogroupWhole Genome SequencingAnti-Bacterial AgentsDiarrheaMultidrug resistanceSalmonella montevideoWaterborne transmissionWhole genome sequencing

Identifiers

PMID41398904
PMCPMC12822100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.