SynthesisMedicine2025
Assessment of bidirectional relationships between sleep traits and frailty: A bidirectional Mendelian randomization study.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comment on "Meeting the 24-Hour Movement Guidelines and Frailty Risk: Evidence From Two Nationally Representative Population Studies and Machine-Learning Models".Geriatrics & gerontology international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the bidirectional causal relationship between sleep traits and frailty via 2-sample Mendelian randomization (MR) approach. Genetic data for sleep traits, including sleep duration, short sleep, long sleep, daytime naps, morning preference, and chronotype, were obtained from large-scale genome-wide association studies. Frailty Index (FI) data were sourced from a meta-analysis of European participants. MR analysis was used to examine causal relationships. Sensitivity analyses, including MR-Egger and MR-PRESSO, were conducted to assess pleiotropy, with heterogeneity tested using Cochran Q test. The Steiger test was used to rule out reverse causality. The results revealed a bidirectional causal relationship between short sleep (≤7 hours) and frailty. Short sleep was associated with a higher FI (β: 0.886, P = 1.24 × 10⁻10), and higher frailty increased the likelihood of short sleep (OR: 1.041, P = .015). No significant associations were found between FI and other sleep traits. Sensitivity analyses confirmed the robustness of these results, with no evidence of pleiotropy or heterogeneity. The Steiger test confirmed the absence of reverse causality. This study demonstrates a strong bidirectional link between short sleep and frailty, underscoring the importance of managing sleep disturbances to prevent frailty in older adults. Monitoring and addressing sleep issues may play a key role in improving health outcomes in aging populations.
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Registered trials
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