Evidence map›Paper›PMID 41398800›Full record

ReviewMedicine2025

Research progress on the mechanisms related to myocardial injury in rats with myocardial ischemia-reperfusion injury treated by acupuncture at neiguan (PC6) acupoint: A narrative review.

Qiuping Xin, Zhixu Gao, Jianen Guo, Yuman Wang, Zhibin Zhang, Yan Liu, Bingran Yang, Jiaying Sun

Abstract readReview
In one paragraph

Review in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiuping XinDepartment of General Medicine, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Zhixu GaoCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.ORCID 0009-0003-3911-5737
Jianen GuoCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.
Yuman WangCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.
Zhibin ZhangCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.
Yan LiuCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.
Bingran YangCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.
Jiaying SunCollege of Traditional Chinese Medicine, Chengde Medical University, Chengde, Hebei, China.

Funding

2022 Hebei Provincial Natural Traditional Chinese Medicine Joint Fund H20224060562024 Hebei Provincial Scientific Research Project in Traditional Chinese Medicine 2024117
6 · The paper itself

Abstract

Acute myocardial infarction presents a considerable clinical burden with high morbidity and mortality rates, with reperfusion therapy being the primary treatment modality. However, following revascularization myocardial ischemia-reperfusion injury can trigger secondary functional cardiac damage, accelerating necrosis of cardiomyocytes. This poses a significant challenge to patient health and well-being. Acupuncture therapy, a cornerstone of traditional Chinese medicine, holds promise in addressing cardiovascular ailments. Neiguan point is an 8 meridians meeting point, belonging to the hand jueyin pericardium meridian, and connected with yinwei meridian. It has the effects of calming the heart and calming the spirit, regulating qi and relieving pain. Modern medical research has confirmed that it can regulate cardiac function through the neuro-humoral-immune network, protect myocardial function, and have a good effect in the treatment of cardiopulmonary diseases. When strategically combined with other acupuncture points, the Neiguan stimulation point exhibits potential in mitigating myocardial ischemia-reperfusion injury. This study explores the impact of acupuncture at the Neiguan point in rats with myocardial ischemia-reperfusion injury, aiming to shed light on preventive and therapeutic strategies for this condition.

Indexed as

Acupuncture PointsAcupuncture TherapyMyocardial Reperfusion InjuryAnimalsDisease Models, AnimalRatsacupuncturemechanismmyocardial ischemia-reperfusion injuryNeiguan point

Identifiers

PMID41398800
PMCPMC12708147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.