Observational studyMedicine2025
Association between neutrophil to high-density lipoprotein cholesterol ratio and 28-day mortality in sepsis patients: Analysis from the MIMIC-IV database.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The neutrophil count-to-high-density lipoprotein cholesterol ratio (NHR), a composite biomarker of lipid metabolism and inflammation, has been regarded as an indicator for predicting clinical outcomes in patients suffering from acute cardiovascular and cerebrovascular disorders. However, the association between the NHR and 28-day all-cause mortality in the sepsis population remains unclear. Our study population comprised 1018 sepsis patients in the Medical Information Mart for Intensive Care IV (MIMIC-IV V2.2) database who were grouped into tertiles based on their NHRs. In this study, curve fitting and 2-piecewise regression models were utilized to analyze the dose-response relationship between the Log NHR and 28-day mortality. The mean age of the participants in the study cohort was 65.0 ± 15.7 years, and 56.3% were men. The 28-day mortality rates for the NHR tertiles were 15% (51), 13.3% (45), and 18.2% (62). By investigating the Log NHR and 28-day mortality, we observed a clear U-shaped relationship. Threshold saturation analysis revealed that when Log NHR below 1.87 (NHR 6.50), with each 1-unit increase in the Log NHR, the risk of 28-day mortality significantly decreased (HR = 0.61, 95% confidence interval: 0.37, 1.01, P = .0526). Conversely, the logNHR for 28-day mortality increased beyond 1.87 (HR = 1.72, 95% confidence interval: 1.18, 2.51; P = .0045). Stratified by age, our analysis revealed nuanced variations in the Log NHR and 28-day mortality association across different age groups. This study revealed a robust U-shaped relationship between the Log NHR and 28-day all-cause mortality in the sepsis population, with a critical threshold of Log NHR = 1.87 (NHR 6.50). This risk is influenced by age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.