Evidence map›Paper›PMID 41398588›Full record

ArticleJournal of nanobiotechnology2025

Engineered macrophage membrane-mimicking nanodrugs activate cGAS/STING pathway to reverse tumor immune suppression after incomplete radiofrequency ablation.

Wei-Hua Zhang, Lei Chen, Lin Gao, Ye-Ming Wu, Zhi-Cheng Jin, Jian-Jian Chen, Yan-Li An, Gao-Jun Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei-Hua Zhang *Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology , Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China.
Lei Chen *Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Lin Gao *Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Basic Medicine Research and Innovation Center of Ministry of Education, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China.
Ye-Ming WuCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology , Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China.
Zhi-Cheng JinCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology , Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China.
Jian-Jian ChenCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology , Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China.
Yan-Li AnCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology , Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China. lyananer@163.com.
Gao-Jun TengCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology , Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China. gjteng@seu.edu.cn.

Funding

Natural Science Foundation of Jiangsu Province BK20251687Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0520400, 2024ZD0520403SEU Innovation Capability Enhancement Plan for Doctoral Students CXJH_SEU 25235The China Postdoctoral Science Foundation 2025M772071the Jiangsu Provincial Medical Innovation Center CXZX202219the National Natural Science Foundation of China 82130060the National Natural Science Foundation of China 82402411the National Natural Science Foundation of China 82502493The Postdoctoral Fellowship Program of CPSF GZC20251385
6 · The paper itself

Abstract

Incomplete radiofrequency ablation (iRFA) often results in tumor recurrence and therapeutic resistance, presenting significant clinical challenges. Tumors subjected to sublethal thermal injury activate the HSP70/ NQO1 antioxidant pathway and secrete elevated levels of CCL2, which recruits macrophages and fosters an immunosuppressive tumor microenvironment. To address these issues, this study engineered copper-doped ZIF-8 nanoparticles that co-deliver the hypoxia-activated prodrug TH-302 and the NQO1-targeting quinone β-lapachone, encapsulated within genetically engineered M1 macrophage membranes overexpressing CCR2 (CCR2-M). This innovative CCR2-M biomimetic coating enhances tumor targeting by sequestering excess CCL2, effectively reducing pro-tumoral macrophage infiltration. β-lapachone selectively targets NQO1-overexpressing tumor cells, elevating intracellular H

Indexed as

MacrophagesMembrane ProteinsNanoparticlesNeoplasmsRadiofrequency AblationAnimalsCell Line, TumorCopperCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansMiceNaphthoquinonesSignal TransductionSTING ProteinTumor Microenvironmentbeta-lapachonecGAS protein, mouseCopperCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNaphthoquinonesSting1 protein, mouseSTING ProteincGAS-STING pathwayIncomplete radiofrequency ablationMacrophage membrane vesicleMetal-organic frameworkPD-L1 mAb.

Identifiers

PMID41398588
PMCPMC12821273

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.