ArticleBritish journal of clinical pharmacology2026
Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug-drug interaction study.
Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results.Age and ageing · 2026Trial
- Article
- Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug-drug interaction study.British journal of clinical pharmacology · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
aimsCannabidiol (CBD), the main non-intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP-mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol, two commonly used analgesics.
methodsThis was an open-label, fixed-sequence, 2-way crossover study in 13 healthy participants. On Day 1, 25 mg amitriptyline and 50 mg tramadol were co-administered orally in a fasted condition, followed by a 7-day washout period. On Day 8, 30 mg CBD was administered orally 1 h prior to amitriptyline and tramadol. Pharmacokinetic sampling was performed for CBD, amitriptyline, tramadol and their respective active metabolites nortriptyline and O-desmethyltramadol for up to 24 h post-dose. The areas under the curve (AUCs) were compared between visits using a mixed effects model.
resultsTwelve participants (4M/8F) completed the study; one participant (M) dropped out for personal reasons. CBD significantly increased the AUC
conclusionsA single dose of 30 mg CBD significantly influenced the metabolism of amitriptyline in healthy volunteers. In patients, CBD-induced drug interactions may be more pronounced in chronic dosing and dependent upon prandial status.
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