Evidence map›Paper›PMID 41398516›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Western Diet Inhibits FUT7-Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease.

Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qian ZhouGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xianfei WangDepartment of Gastroenterology, Digestive Endoscopy Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Teng BenGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Chunping ZhuDepartment of Gastroenterology, Ganzhou Hospital Affiliated to Nanfang Hospital, Southern Medical University, Ganzhou, 341099, China.
Xinlong LinGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yinmu LiGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xinyue ZhangGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yeling ChenGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yuchen XuanGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Huaiwen ChenSunlipo Biotech Research Center for Nanomedicine, 3688 Tingwei Road, Shanghai, 201507, China.
Ke LiuGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Fang WuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 32500, China.
Yuexin RenGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Gao TanGuangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0002-6959-2249

Funding

National Natural Science Foundation of China 81970492National Natural Science Foundation of China 82270547National Natural Science Foundation of China 82370541Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University 2021J009Science and technology + National Regional Medical Center Joint Project 2022-RC1450Zhejiang Provincial Natural Science Foundation of China LHDMY23H100001
6 · The paper itself

Abstract

The Western diet (WD) is a potential risk factor for developing Crohn's disease (CD), characterized by disordered homeostasis of intestinal epithelial cells (IECs). However, how WD disrupts the IEC homeostasis remains unclear. Here, it is shown that WD disrupts the IEC homeostasis through inhibiting Fut7-mediated Treg intestinal homing to weaken Treg and IEC signaling crosstalk. In this study, it is found that WD disrupted the IEC barrier, downregulated Fut7 expression in Tregs, and decreased colonic Tregs. The combined analyses of single-cell RNA-sequencing and spatial transcriptomics revealed that WD weakened the intestinal homing ability of Tregs and the signaling crosstalk between Tregs and IECs. Furthermore, Treg-specific Fut7 knockout decreased colonic Tregs and aggravated the severity of colitis and IEC barrier disruption in the 2,4,6-trinitrobenzenesulfonic acid-induced mouse CD model, while upregulation of Fut7 in Tregs alleviated their severity. On top of this model, transfer of Tregs in vivo ameliorated colitis and IEC barrier disruption in the naive CD4

Indexed as

Crohn DiseaseDiet, WesternEpithelial CellsFucosyltransferasesHomeostasisIntestinal MucosaT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalGalactoside 2-alpha-L-fucosyltransferaseHumansMaleMiceMice, Inbred C57BLMice, KnockoutFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseCrohn's diseaseepithelial barrierFUT7treg cellwestern diet

Identifiers

PMID41398516
PMCPMC12955945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.