ArticleMikrochimica acta2025
Hydrophilic maltose-functionalized magnetic graphene covalent organic frameworks composites for highly selective enrichment of glycopeptides.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A novel hydrophilic adsorbent of maltose-functionalized magnetic graphene covalent organic frameworks (denoted as MagGO@COF@Maltose) composites was designed and fabricated for highly selective enrichment of glycopeptides. The COF shell coating on the surface of magnetic graphene could provide highly abundant anchors to introduce large amount of hydrophilic maltose which endowed the composites with superior hydrophilicity. Benefited from this, the MagGO@COF@Maltose composites exhibited exceptional enrichment efficiency including high enrichment sensitivity (0.1 fmol µL− 1), excelent enrichment selectivity (1:2000, horseradish peroxidase (HRP) tryptic digest to bovine serum albumin (BSA) tryptic digest) and high adsorption capacity (100 µg mg− 1). In addition, the MagGO@COF@Maltose composites possessed rapid magnetic responses, good reusability and long-term storage stability. Finally, 279 endogenous N-glycopeptides derived from 70 glycoproteins with 78 N-glycosylation sites were enriched by the MagGO@COF@Maltose composites from human saliva sample, demonstrating their great potential in highly selective enrichment of glycopeptides from complex biological samples for comprehensive glycoproteomic determination.
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