Evidence map›Paper›PMID 41398460›Full record

ArticleCommunications psychology2025

No disconnection syndrome after near-complete callosotomy.

Selin Bekir, Johanna L Hopf, Theresa Paul, Valerie M Wiemer, Tyler Santander, Henri E Skinner, Anna Rada, Friedrich G Woermann, Thilo Kalbhenn, Barry Giesbrecht and 5 more

Abstract read
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In one paragraph

Article in Communications psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Selin BekirDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA. sbekir@ucsb.edu.ORCID http://orcid.org/0000-0003-2292-5269
Johanna L HopfDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Theresa PaulMedical Faculty, University of Cologne, and Department of Neurology, University Hospital Cologne, Cologne, Germany.
Valerie M WiemerMedical Faculty, University of Cologne, and Department of Neurology, University Hospital Cologne, Cologne, Germany.
Tyler SantanderDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.
Henri E SkinnerDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.
Anna RadaDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Friedrich G WoermannDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Thilo KalbhennDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.ORCID http://orcid.org/0000-0001-6249-629X
Barry GiesbrechtDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-1976-1251
Christian G BienDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Olaf SpornsDepartment of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA.ORCID http://orcid.org/0000-0001-7265-4036
Michael S GazzanigaDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.
Lukas J Volz *Medical Faculty, University of Cologne, and Department of Neurology, University Hospital Cologne, Cologne, Germany.
Michael B Miller *Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA. mbmiller@ucsb.edu.ORCID http://orcid.org/0000-0001-7049-6062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensorimotor processing in the human brain is largely lateralized, with the corpus callosum integrating these processes into a unified experience. Following complete callosotomy, this integration breaks down, resulting in disconnection syndromes. We asked how much of the corpus callosum is sufficient to support functional unity-the absence of disconnection syndrome-by comparing three complete callosotomy patients with one retaining only the splenium. Using lateralized tasks across visual, tactile, visuospatial, and language domains, we predicted domain-specific deficits in the splenium-only patient based on established anatomical models of callosal topography. Strikingly, while complete callosotomy patients exhibited disconnection syndromes, the splenium patient demonstrated functional unity across all domains-as if his entire corpus callosum were intact. Our findings highlight the brain's remarkable capacity to maintain behavioral integration through minimal preserved pathways, highlighting how the structure-dependent reorganizational capacity of the human brain may allow to preserve functional unity.

Identifiers

PMID41398460
PMCPMC12808738

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.