Evidence map›Paper›PMID 41398456›Full record

ArticleNPJ digital medicine2025

A randomized clinical trial of app cognitive behavior therapy vs. HealthWatch for obsessive compulsive disorder.

Sabine Wilhelm, Jennifer L Greenberg, Ryan J Jacoby, Hilary Weingarden, Susanne S Hoeppner, Dalton Klare, Ivar Snorrason, Adam C Jaroszewski, Thomas H McCoy, Oliver Harrison

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04136626 (Digital Health Interventions for Obsessive Compulsive Disorder), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04136626 nacompletednot on this map

Digital Health Interventions for Obsessive Compulsive Disorder: A Randomized Controlled Trial

TypeinterventionalSponsorMassachusetts General HospitalRan2021 to 2024Enrolled120ConditionsObsessive-Compulsive DisorderArmsPerspectives OCD, The Health and Well-Being Program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sabine WilhelmMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA. swilhelm@mgh.harvard.edu.
Jennifer L GreenbergMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ryan J JacobyMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Hilary WeingardenMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Susanne S HoeppnerMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dalton KlareMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ivar SnorrasonMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Adam C JaroszewskiMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Thomas H McCoyMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Oliver HarrisonKoa Health, London, UK.

Funding

Targeting Attentional and Cognitive Control to Enhance the Transdiagnostic Treatment of Repetitive Negative ThinkingK23MH120351 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JACOBY, RYAN J · 2020 to 2024
$977k
Smartphone-based digital phenotyping to detect high-risk affect states in body dysmorphic disorderK23MH119372 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WEINGARDEN, HILARY · 2019 to 2024
$922k
A Randomized Controlled Trial of A Smartphone Delivered Treatment for Suicidal Thoughts and BehaviorK23MH133876 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Adam Jaroszewski · 2024 to 2026
$586k
NIMH NIH HHS K23 MH119372NIMH NIH HHS K23MH119372NIMH NIH HHS K23 MH120351NIMH NIH HHS K23MH120351NIMH NIH HHS K23 MH133876
6 · The paper itself

Abstract

App-based cognitive behavioral therapy (app-CBT) addresses many treatment barriers. We randomized 120 U.S. adults with primary OCD (82.4% female, 77.5% White, mean age 40.1) between 7/2021 and 7/2023 to 12-weeks of coach-guided Perspectives (n = 60; app-CBT) or coach-guided HealthWatch (n = 60; an online well-being program). OCD severity (Yale-Brown Obsessive Compulsive Scale; primary outcome) analyzed using a pre-registered mixed linear model showed a trend level group difference at post-treatment (ES = -0.47; p = 0.079). However, results from secondary and sensitivity analyses showed significantly better outcomes in Perspectives after adjusting for baseline differences or varying missing data assumptions (ps < 0.05). Response rates among completers were 65% in Perspectives and 41% in HealthWatch. Perspectives was also associated with greater pre-to-post-treatment improvement in functioning (ES = -0.55; p = 0.014). 83% of completers in Perspectives were mostly/very satisfied and 91% recommended the program vs. 43% and 53% in HealthWatch. Results highlight app-CBT as an effective and feasible treatment option for OCD that addresses dissemination obstacles.Clinicaltrials.gov identifier: NCT04136626 (Registration Date: 10/17/2019).

Identifiers

PMID41398456
PMCPMC12753652

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.