Evidence map›Paper›PMID 41398438›Full record

ArticleScientific reports2025

Antimalarial potential of curcumin derivatives evaluated through experimental and computational approaches.

Siti Nur Hidayah Jamil, Khairul Azreena Bakar, Amatul Hamizah Ali, Nur Fatin Najihah Marzuki, Fatima Shahid, Fauze Mahmud, Shevin Rizal Feroz, Su Datt Lam, Natsuhisa Oka, Yusmazura Zakaria and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Siti Nur Hidayah JamilDepartment of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia.
Khairul Azreena BakarDepartment of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia.
Amatul Hamizah AliDepartment of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia.
Nur Fatin Najihah MarzukiBiomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu 16150, Kelantan, Malaysia.
Fatima ShahidDepartment of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia.
Fauze MahmudFaculty of Science and Technology, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, 88400, Malaysia.
Shevin Rizal FerozDepartment of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia.
Su Datt LamDepartment of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia.
Natsuhisa OkaInternational Joint Department of Materials Science and Engineering between, Graduate School of Engineering, National University of Malaysia and Gifu University, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Yusmazura ZakariaBiomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu 16150, Kelantan, Malaysia.
Muhamad Imam MuhajirDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, West Java, Indonesia.
Rani MaharaniDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, West Java, Indonesia.
Unang SupratmanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, West Java, Indonesia.
Jalifah LatipDepartment of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, 43600, Selangor, Malaysia. jalifah@ukm.edu.my.

Funding

Foreign, Commonwealth and Development Office ST-2024-001Universiti Kebangsaan Malaysia DIP-2024-006
6 · The paper itself

Abstract

Malaria remains a leading global health threat, with cases and deaths continually increasing each year. The rising number of drug-resistant cases further diminishes the effectiveness of current antimalarials, highlighting the need for potent and effective new compounds. Curcumin, a natural polyphenol, has been extensively studied for its therapeutic properties. However, its clinical use is limited by poor bioavailability. This study evaluates curcumin derivatives as potential antimalarial agents through in-silico screening and biological assessments, aiming to identify promising candidates for further development. For the first time, we reveal the multi-target mechanisms of action of these derivatives, focusing on their potential for immunomodulatory GSK-3β inhibition and haemin binding. The ten synthesised compounds, which include Knoevenagel condensates, heterocyclic pyrazoles, and monocarbonyl derivatives, show favourable GSK-3β binding and improved specific ADMET parameters compared to curcumin, along with favourable electronic and reactivity profiles. These compounds also demonstrate greater potency than curcumin against both P. falciparum CQ-sensitive 3D7 and multidrug-resistant K1 strains. Notably, monocarbonyl derivative 20 exhibited the most potent EC

Indexed as

AntimalarialsCurcuminPlasmodium falciparumGlycogen Synthase Kinase 3 betaHemeproteinsHumansMolecular Docking SimulationAntimalarialsCurcuminGlycogen Synthase Kinase 3 betaHemeproteinshemozoinAntimalariaAntiplasmodialCurcumin derivativesDFT calculationsGSK-3βIsothermal titration calorimetry (ITC)

Identifiers

PMID41398438
PMCPMC12819389

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.