ArticleScientific reports2025
Impact of thyroid dysfunction and diabetes on fibrosis and steatosis stages in metabolic dysfunction associated fatty liver disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Hypothyroidism and Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms, Clinical Links, and Therapeutic Implications.Current obesity reports · 2026Review
- Noninvasive Detection of Clinically Significant Fibrosis in Biopsy-Proven MASLD: A Retrospective Cross-Sectional Diagnostic Accuracy Study.Medicina (Kaunas, Lithuania) · 2026Article
- Exercise-Induced Hepatic Mitochondrial Reprogramming Across Muscle-Gut-Thyroid Axes in MASLD/MASH.International journal of molecular sciences · 2026Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Metabolic dysfunction associated fatty liver disease (MAFLD) is a common metabolic disorder intricately linked to diabetes and thyroid dysfunction. Hypothyroidism, characterized by elevated thyroid-stimulating hormone (TSH), may disrupt lipid metabolism and exacerbate insulin resistance, contributing to MAFLD progression. Investigating the combined impact of diabetes and thyroid dysfunction on fibrosis and steatosis stages in MAFLD is essential for optimizing disease management. This prospective cross-sectional study was conducted at Suez General Hospital from March to September 2024 and included 400 patients with MAFLD . Participants were stratified into four groups: Group A: 100 diabetic patients without thyroid dysfunction; Group B: 100 non-diabetic patients without thyroid dysfunction; Group C: 100 diabetic patients with thyroid dysfunction; and Group D: 100 non-diabetic patients with thyroid dysfunction. Clinical assessment, laboratory investigations, fibrosis-4 (FIB-4) scores, and abdominal ultrasonography were performed for all participants, and transient elastography (FibroScan
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