Evidence map›Paper›PMID 41398396›Full record

ArticleNature microbiology2026

Zoonotic Streptococcus imports glucose to inhibit stringent response and promote growth during meningitis.

Chen Yuan, Karthik Hullahalli, Hao Huang, Siqi Zhao, Wenqing Wang, Xingyu Tian, Xin Li, Linya Xia, Yuchang Wang, Fei Pan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Development of a GFP-labeledApplied and environmental microbiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chen YuanMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Karthik HullahalliHoward Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases, and Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Hao HuangMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Siqi ZhaoMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Wenqing WangMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Xingyu TianMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Xin LiMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.ORCID http://orcid.org/0000-0002-6423-3060
Linya XiaMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Yuchang WangMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Fei PanMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Ying LiangMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Yurui XieMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Yue LiMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Hongjie FanMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.ORCID http://orcid.org/0000-0002-3001-0133
Matthew K WaldorHoward Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases, and Department of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1843-7000
Zhe MaMinistry of Agriculture Key Laboratory of Animal Bacteriology, the International Joint Laboratory of Animal Health and Food Safety, and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China. mazhe@njau.edu.cn.ORCID http://orcid.org/0000-0002-5212-5759

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Molecular Biology and Virulence of CTX PhageR37AI042347 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WALDOR, MATTHEW K · 2008 to 2017
$3.8M
Howard Hughes Medical Institute (HHMI) RO1- AI-042347National Natural Science Foundation of China (National Science Foundation of China) 32273009, 31973004Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation) BK20250095NIAID NIH HHS R01 AI042347NIAID NIH HHS R37 AI042347
6 · The paper itself

Abstract

Proliferation of the emerging zoonotic pathogen Streptococcus equi subsp. zooepidemicus in the meninges is linked to mortality in pigs and morbidity in humans. The mechanisms underlying the remarkable capacity of hypervirulent S. zooepidemicus to proliferate in cerebrospinal fluid (CSF) are largely undefined. Here, using genetically barcoded S. zooepidemicus, we found that following systemic infection of mice, only ~1-10 S. zooepidemicus clones invade the meninges where they subsequently replicate ~10

Indexed as

GlucoseMeningitis, BacterialStreptococcal InfectionsStreptococcus equiAnimalsBacterial ProteinsDisease Models, AnimalFemaleGene Expression Regulation, BacterialHumansMeningesMicePromoter Regions, GeneticVirulenceBacterial ProteinsGlucose

Identifiers

PMID41398396
PMCPMC12768970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.