ArticleJournal of human hypertension2026
Subclinical left ventricular systolic impairment in hypertensive patients: insights from 2d speckle-tracking echocardiography.
Article in Journal of human hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases, the leading global cause of mortality, are frequently driven by hypertension, which contributes to left ventricular hypertrophy (LVH) and heart failure. Although ejection fraction (EF) remains the standard metric for assessing left ventricular function, it often fails to detect early dysfunction. Speckle-tracking echocardiography (STE) provides a more sensitive approach to identifying subclinical myocardial strain changes before EF declines. This cross-sectional, case-control study evaluated 90 participants divided into three groups: 30 healthy controls (Group I), 40 hypertensive patients without LVH (Group II), and 20 hypertensive patients with LVH (Group III). All underwent clinical evaluation, conventional echocardiography, and 2D-STE. Results showed that Group III had significantly greater septal and posterior wall diastolic thickness (p = 0.001) and higher LV mass index (p = 0.001) compared to Groups I and II. 2D-STE revealed reduced apical (AP2Ls, AP3Ls) and global longitudinal strain (GLS) in Groups II and III versus controls. Basal and mid-segment strains were also lower in disease groups, with mid-inferolateral segments showing more pronounced impairment in Group III. These findings highlight that Group III exhibited the most severe structural and functional cardiac alterations. The study demonstrates the superiority of 2D-STE over conventional echocardiography in detecting subclinical LV dysfunction in hypertensive patients, particularly those with LVH, through impaired longitudinal strain measurements. Early integration of 2D-STE into clinical practice could facilitate timely interventions to mitigate myocardial remodeling and heart failure progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.