ArticleNature genetics2026
Natural variation in OsTPS8 confers differential regulation of chalkiness and seed vigor in indica and japonica rice.
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Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Metabolic Rewiring of the Shikimate Pathway Enables Rose-Scented Rice.Plant biotechnology journal · 2026Article
- Genome-wide identification of the kiwifruit AcTPS family and analysis of its drought-responsive expression patterns.BMC plant biology · 2026Article
- Mitigating rice chalkiness while ensuring grain quality and seed vigor.Plant communications · 2026Article
- D-amino acid aminotransferase1 regulates grain chalkiness in rice by modulating endoplasmic reticulum stress response.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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30 authors.
Xiaoli Chen *State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0002-0303-5570
Yulong Ren *State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Hui Dong *State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Xiaokang Jiang *State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Xiaoming ZhengState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Erchao DuanState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Xuan TengState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Yunlong WangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Chuanwei GuState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Rongbo ChenState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Qingkai WangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.ORCID 0009-0009-4838-4182
Yongfei WangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Yipeng ZhangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Rushuang ZhangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Yunpeng ZhangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Wenjie ZhaoState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Yu ZhangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Xue YangState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Lei ZhouState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Chao LiState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Tiaofeng ShanState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Yiqun BaoCollege of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Yunlu TianState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Xi LiuState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Shijia LiuState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Tao GuoState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Mingjiang ChenState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China.
Haiyang WangState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China. wanghaiyang@caas.cn.ORCID 0000-0002-1302-5747
Yihua Wang *State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China. yihuawang@njau.edu.cn.ORCID 0000-0003-1945-1277
Jianmin WanState Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Zhongshan Biological Breeding Laboratory, Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station, Nanjing Agricultural University, Nanjing, China. wanjm@njau.edu.cn.ORCID 0000-0002-0017-8760
Funding
National Natural Science Foundation of China (National Science Foundation of China) 31921004National Natural Science Foundation of China (National Science Foundation of China) 32272168National Natural Science Foundation of China (National Science Foundation of China) 32372164
Abstract
Chalkiness and seed vigor are major agronomic traits affecting rice grain quality and productivity, respectively. Little is known about the intrinsic relationship and the regulatory mechanisms of these two traits. Here we identified a chalkiness locus qPGWC-8, which encodes trehalose-6-phosphate synthase 8 (OsTPS8) that suppresses trehalose-6-phosphate (Tre6P) biosynthesis by interacting with and inhibiting OsTPS1. A natural promoter variation in OsTPS8 confers differential transcriptional regulation by OsbHLH001. Elevated expression of OsTPS8 reduces Tre6P levels and activates the expression of OsMYBS1 and α-amylase genes, thus promoting starch degradation, chalkiness formation and seed vigor elevation. Two major haplotypes, OsTPS8
Indexed as
GlucosyltransferasesOryzaPlant ProteinsSeedsGene Expression Regulation, PlantGenetic VariationHaplotypesPlants, Genetically ModifiedPromoter Regions, GeneticStarchTrehaloseGlucosyltransferasesPlant ProteinsStarchTrehalosetrehalose-6-phosphate synthase
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