Evidence map›Paper›PMID 41398299›Full record

ReviewVeterinary research2025

Evolutionary and structural insights into VP1 epitopes of representative SAT-type FMDV strains: implications for candidate vaccine selection.

Shuaiyu Jiang, Shunli Yang, Xiaoqing Zhang, Yupeng Fang, Ziwei Guo, Zhiyong Ma, Xiaoxue Wei, Kuanjia Guo, Ramy E El-Ansary, Chimedtseren Bayasgalan and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shuaiyu JiangHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Shunli YangHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Xiaoqing ZhangHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Yupeng FangHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Ziwei GuoHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Zhiyong MaHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Xiaoxue WeiHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Kuanjia GuoHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China.
Ramy E El-AnsaryZoology and Entomology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Chimedtseren BayasgalanSchool of Veterinary Medicine, Mongolian University of Life Sciences, Ulaanbaatar, 17024, Mongolia.
Ashenafi Kiros WubshetShandong Binzhou Institute of Animal Husbandry and Veterinary Sciences, Binzhou, China.
Jie ZhangHebei Key Laboratory of Preventive Veterinary Medicine, Hebei Normal University of Science and Technology, Qinhuangdao, 066000, Hebei, China. zhangj4032@hevttc.edu.cn.

Funding

National key R&D Program of China Intergovernmental International S&T Innovation Cooperation Program 2023YFE0199900
6 · The paper itself

Abstract

Foot-and-mouth disease (FMD) is a highly contagious viral disease primarily affecting cloven-hoofed animals, with outbreaks causing substantial economic losses. This review summarizes the global epidemiological landscape of Southern African Territories (SAT) serotypes of FMD virus (FMDV) from 2010 to May 2025, with a particular emphasis on the topotypic diversity and transboundary spread of SAT2 strains. By integrating phylogenetic analysis and epitope characterization of the VP1 capsid protein, we provide preliminary insights into the evolutionary trajectories of SAT-type FMDVs and their implications for vaccine design. In light of the challenges posed by frequent antigenic drift and poor vaccine matching, we strictly assess the current status of commercial multivalent inactivated vaccines and recent advances in empty capsid subunit vaccine technologies. Comparative evaluation of these strategies underlines the need for enhanced molecular surveillance and rational vaccine optimization to mitigate the ongoing spread of SAT-type FMDV.

Indexed as

Capsid ProteinsEpitopesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusViral VaccinesAnimalsEvolution, MolecularPhylogenySerogroupCapsid ProteinsEpitopesViral VaccinesVP1 protein, Foot-and-mouth disease virusempty capsid subunit vaccineepidemiologyFoot-and-mouth diseaseSAT serotypesvaccineVP1 protein

Identifiers

PMID41398299
PMCPMC12706929

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.