ArticleBMC infectious diseases2025
Impact of baseline lymphopenia on prognosis of patients with septic shock.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis.BMC infectious diseases · 2026Article
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10 authors.
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Abstract
backgroundSepsis is defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Lymphocytes play an important role in sepsis, but little is known about the comparisons of different lymphopenia and non-lymphopenia patients with septic shock. The aim of this study is to compare the clinical characteristics of patients with septic shock among pre-existing lymphopenia group, sepsis-induced lymphopenia group, and non-lymphopenia group, and to identify the relationship of different lymphopenia with outcomes.
methodsThis retrospective study included 354 septic-shock patients with baseline lymphocyte available during 2013 and 2023, which were divided into pre-existing lymphopenia group, sepsis-induced lymphopenia group, and non-lymphopenia group. We compared the clinical characteristics and identified the relationship of different lymphopenia with 30-day mortality by univariate analysis and multivariable logistic regression analysis.
resultsAmong 354 patients with septic shock with baseline lymphocyte available, the pre-existing lymphopenia group (n = 159) exhibited the highest 30-day mortality (50.9%), while the mortality in sepsis-induced lymphopenia patients (n = 143) and non-lymphopenia groups (n = 52) was 37.1% and 44.2%, respectively (p = 0.069). Multivariable analysis showed that pre-existing lymphopenia was an independent risk factor for 30-day mortality (OR 3.67, 95% CI 1.61–8.79), while lymphopenia at ICU admission was not (OR 0.95, 95% CI 0.28–3.37).
conclusionPre-existing lymphopenia was an independent risk factor for 30-day mortality in patients with septic shock, while sepsis-induced lymphopenia at ICU admission was not. These results suggest that historical lymphocyte count level should be incorporated into risk stratification paradigms for septic shock patients.
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