ArticleScientific reports2025
Study on the anti-tumor effect of Wall-broken ganoderma lucidum spore powder on papillary thyroid cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- GLSP ameliorates monocrotaline-induced pulmonary arterial hypertension through inhibition of the PI3K/AKT and MAPK signaling pathways.Journal of molecular histology · 2026Article
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11 authors.
Funding
Abstract
Wall-broken Ganoderma lucidum spore powder (BGLSP), a traditional Chinese medicinal substance, contains bioactive triterpenoids with anti-tumor potential. However, its efficacy and mechanisms against papillary thyroid cancer (PTC) remain unclear. This study investigated the anti-tumor effects of BGLSP on PTC using three human PTC cell lines (TPC-1, K1, KTC-1) treated with BGLSP (0.5-4 mg/mL). We assessed cell viability (CCK-8 assay), proliferation (colony formation, Ki-67 immunofluorescence), apoptosis (flow cytometry, caspase activation), and migration (wound healing, transwell assays). Western blot analyzed the key Epithelial-Mesenchymal Transition (EMT) markers, including E-cadherin, N-cadherin, Vimentin, Zonula occludens-1 (ZO-1), Snail and Zinc-finger E-box binding homeobox 1 (ZEB1), while a nude mouse xenograft model assessed BGLSP efficacy (2 mg/kg/day). Results showed that BGLSP significantly inhibited PTC cell proliferation and colony formation while inducing apoptosis via caspase-8/caspase-3 activation. It also suppressed migration by modulating EMT, upregulating epithelial markers (E-cadherin, ZO-1), and downregulating mesenchymal markers (N-cadherin, Vimentin) and EMT-transcription factors (Snail, ZEB1). In vivo, BGLSP reduced tumor growth and Ki-67 expression, consistent with in vitro findings. These findings demonstrate that BGLSP exerts anti-tumor effects in PTC by targeting proliferation, apoptosis, and EMT, supporting its traditional use and suggesting potential as a natural adjuvant therapy worthy of further studies.
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