ArticleBiological trace element research2026
Co-exposure to Hexavalent Chromium and Polyamide Microplastics Alters Growth, Hematology, Histopathology of Tissues and Immune Genes Expression in Striped Catfish (Pangasianodon hypophthalmus).
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microplastics Induced Dysfunctions in Physiology and Behavior of Fish: A Comprehensive Review.Journal of toxicology · 2026Review
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6 authors.
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Abstract
Hexavalent chromium (Cr6+) and microplastics (MP) are considered pervasive pollutants in aquatic environments and its exceeding limit could produce serious cytotoxic effects in fish. In view of that, a 28-day trial was designed where juvenile striped catfish (Pangasianodon hypophthalmus) were subjected to a sub-lethal concentration of chromium (Cr6+; 3.2 mg/L) and polyamide microplastic (PA-MP; 10 mg/L) alone or combined. Three different waterborne treatments i.e. T1 (PA-MP); T2 (Cr6+); and T3 (Cr6++PA-MP) including a control (no Cr6+ or PA-MP) with three replicates for each were incorporated. The results exhibited that the exposure of Cr6+ increased ingestion of PA-MP in T3. Compromised weight gain (g), apparent feed conversion ratio (AFC) and survival percentages were observed in co-exposure group. Blood indices including mean concentrations of hemoglobin and glucose were found to be 1.37- and 1.21-fold higher than those of the control, respectively. The frequencies of nuclear and cellular abnormalities were recorded maximum in T3 (1.64% and 5.08%) and subsequently in T2. However, the co-exposure of Cr6+ and PA-MP escalated the severity of histopathological abnormalities in gills, liver, kidney, and intestine as well. Besides, significantly upregulated expression of Interleukin-1β (IL-1β) mRNA was estimated in T3 (p < 0.05). In contrast, the relative fold change of Major compatibility complex-II (MHC-II), Interferon-γ-α2 (IFN-α2) and Interferon-γ-β2 (IFN-β2) mRNA estimated lowest due to combined exposure. Finally, the overall performance of juvenile striped catfish relatively exacerbated in co-exposure group in terms of its weight gain, feeding efficiency, survival, hemato-biochemistry, histopathological changes and immune-related genes expression based on principal component analysis (PCA).
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