Evidence map›Paper›PMID 41398113›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Outcomes in prenatal vs. postnatal surgery for myelomeningocele: a systematic review and meta-analysis.

João Pedro Veras Torres, Helvécio Neves Feitosa Filho, Rian Vilar Lima, Leonardo Brito de Souza, Lucas Evangelista de Andrade, Matheus Oliveira Ribeiro, Vinícius Garcia Costa E Melo, Antônio Aldo Melo Filho, Vitor Nagai Yamaki, Carlos Eduardo Barros Jucá

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

João Pedro Veras TorresSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil. jpverastorres.med@gmail.com.ORCID 0009-0005-0599-4192
Helvécio Neves Feitosa FilhoSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0009-0002-1950-6629
Rian Vilar LimaSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0000-0003-2405-1753
Leonardo Brito de SouzaSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0009-0002-0274-6001
Lucas Evangelista de AndradeSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0009-0003-3414-0837
Matheus Oliveira RibeiroSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0009-0003-5680-4657
Vinícius Garcia Costa E MeloSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0009-0004-0428-794X
Antônio Aldo Melo FilhoSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0000-0002-8068-2632
Vitor Nagai YamakiDepartment of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-4872-1731
Carlos Eduardo Barros JucáSchool of Medicine, Universidade de Fortaleza, Av. Washington SoaresEdson Queiroz, CEP 60.811-905, Fortaleza, CE, 1321, Brazil.ORCID 0000-0003-3269-2577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was aimed at comparing the outcomes of fetal versus postnatal surgery for myelomeningocele through a systematic review and meta-analysis.

methodsIn accordance with the PRISMA guidelines, systematic searches of Medline, Embase, Web of Science, and Cochrane Central were undertaken from database inception to December 2024. Outcomes analyzed included neonatal and maternal complications, indication rate of ventriculo-peritoneal shunting (VPS), and long-term motor outcomes in children. Using a random-effects model, we evaluated clinical and functional outcomes. Sensitivity analyses addressed heterogeneity.

resultsEleven studies reporting on 751 patients undergoing in utero repair of myelomeningocele and 1169 undergoing postnatal repair. Fetal surgery significantly reduced the need for VPS (OR 0.08; CI 0.03-0.22; I

conclusionsThis study demonstrates that fetal surgery significantly reduces hydrocephalus and improves motor outcomes compared to postnatal repair, though it is associated with higher rates of maternal complications.

Indexed as

Fetal TherapiesMeningomyeloceleNeurosurgical ProceduresFemaleHumansInfant, NewbornPregnancyTreatment OutcomeVentriculoperitoneal ShuntFetal surgeryMyelomeningocelePostnatal surgeryPrenatal surgery

Identifiers

PMID41398113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.