ReviewHandbook of experimental pharmacology2026
Hydrogen Sulfide Consumption and Cell Bioenergetics in Human (Patho)physiology.
Review in Handbook of experimental pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hydrogen sulfide (H₂S), once considered merely a toxic gas, is now recognized as a key endogenous signaling molecule with profound effects on vascular tone, inflammation, and cytoprotection. Central to its physiological roles is a tightly regulated balance between synthesis and degradation. While much attention has been given to H₂S biosynthesis and its signaling functions, its catabolism - particularly through the mitochondrial sulfide oxidizing pathway - has received comparatively less pharmacological exploration. This pathway not only serves as a critical detoxification mechanism but also links H₂S oxidation directly to cellular bioenergetics by contributing to mitochondrial ATP production. Such coupling underscores a unique intersection between gasotransmitter regulation and energy metabolism. This chapter highlights the bioenergetic significance of H₂S degradation, emphasizing how modulation of its mitochondrial catabolic machinery could serve as a novel therapeutic strategy. By modulating H₂S clearance, especially in pathologies marked by disrupted sulfur homeostasis and mitochondrial dysfunction, targeted pharmacological intervention may restore metabolic balance and cellular energy efficiency.
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