Evidence map›Paper›PMID 41398089›Full record

ArticleAnalytical and bioanalytical chemistry2026

Evaluating the chemical safety of bio-based and biodegradable food packaging materials through non-targeted LC-HRMS analysis and in vitro bioassays.

P Vázquez-Loureiro, R Cariou, L Barbosa-Pereira, A Katsumiti, I Polanco Garriz, F Goñi de Cerio, G Dervilly, B Le Bizec, A Lestido-Cardama, R Sendón and 3 more

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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

P Vázquez-LoureiroDepartment of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
R CariouOniris, INRAE, LABERCA, 44300, Nantes, France.
L Barbosa-PereiraDepartment of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
A KatsumitiGAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, Spain.
I Polanco GarrizGAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, Spain.
F Goñi de CerioGAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, Spain.
G DervillyOniris, INRAE, LABERCA, 44300, Nantes, France.
B Le BizecOniris, INRAE, LABERCA, 44300, Nantes, France.
A Lestido-CardamaDepartment of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
R SendónDepartment of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
J BustosNational Food Center, Spanish Agency of Food Safety and Nutrition, E-28220, Majadahonda, Spain.
P Paseiro LosadaDepartment of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
A Rodríguez Bernaldo de QuirósDepartment of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. ana.rodriguez.bernaldo@usc.es.

Funding

Agencia Estatal de Investigación Ref.No. PID2021-124729NB-I00Fondo Europeo de Desarrollo Regional (FEDER) Ref.No. PID2021-124729NB-I00Ministerio de Ciencia e Innovación Ref.No. PID2021-124729NB-I00
6 · The paper itself

Abstract

Bio-based and/or biodegradable polymers like all food-contact materials shall not transfer their constituents to food in quantities which could endanger human health. This work aims to evaluate the chemical safety of food contact bioplastics through an approach that combines a non-targeted liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analysis emphasizing low-molecular weight oligomers and in vitro bioassays, including cytotoxicity assay, ROS production, inflammation tests, and in vitro assays to assess the endocrine activity. Seventeen samples including bio-polypropylene, bio-polyethylene, bio-polyester-based materials, bio-polyester-polyvinyl alcohol (PVOH), and polylactic acid (PLA)-based materials were assessed. A variety of different families of oligomers, specifically oligoesters, caprolactone oligomers, cyclic and linear oligomers of lactic acid (LA), and methoxylated and ethoxylated LA linear oligomers, were identified. Additives as well as their degradation products were also detected. An extract from each type of material was subjected to in vitro bioassays as part of hazard identification. The results showed that PLA, bio-polyester, and bio-polyester-PVOH showed the highest cytotoxicity, and bio-polypropylene and bio-polyethylene exhibited endocrine-disrupting potential. Furthermore, extracts from PLA have been shown to induce inflammation through high ROS production.

Indexed as

Biodegradable PlasticsBiological AssayFood PackagingMass SpectrometryAnimalsChromatography, LiquidHumansMicePolyestersBiodegradable PlasticsPolyesterspoly(lactide)BioplasticsFood contactIn vitro bioassaysLC-HRMSOligomersSafety

Identifiers

PMID41398089

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.