Evidence map›Paper›PMID 41398087›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

No reinduction of clinically relevant radioiodine uptake after lenvatinib treatment in radioidine-refractory differentiated thyroid cancer.

Maaike Dotinga, Lioe-Fee de Geus-Oei, Floris H P van Velden, Mette K Stam, Jan W T Heemskerk, Petra Dibbets-Schneider, Martin Pool, Frits Smit, Dennis Vriens, Ellen Kapiteijn

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maaike DotingaDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-8384-7164
Lioe-Fee de Geus-OeiDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-1817-2743
Floris H P van VeldenDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2859-2119
Mette K StamDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0009-0004-2843-1854
Jan W T HeemskerkDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0145-1009
Petra Dibbets-SchneiderDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0538-8270
Martin PoolDepartment of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-4892-3109
Frits SmitDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Dennis Vriens *Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-5762-6766
Ellen Kapiteijn *Department of Medical Oncology, Leiden University Medical Center, PO box 9600, Leiden, 2300 RC, The Netherlands. h.w.kapiteijn@lumc.nl.ORCID 0000-0002-4814-6426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior studies show that short-term treatment using tyrosine kinase inhibitors (TKIs) can reinduce radioiodine uptake and warrant

methodsNine RAI-R DTC patients starting lenvatinib treatment for progressive advanced or metastatic disease, were included and underwent rhTSH-stimulated

resultsBy our definition, none of the patients were found eligible for

conclusionRedifferentiation of RAI-R DTC to reinduce radioiodine uptake to a level that warrants

Indexed as

Iodine RadioisotopesPhenylurea CompoundsQuinolinesThyroid NeoplasmsAdultAgedBiological TransportFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyIodine RadioisotopeslenvatinibPhenylurea CompoundsQuinolines124IDosimetryLenvatinibRadioiodine refractoryRedifferentiationThyroid cancer

Identifiers

PMID41398087
PMCPMC13121206

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.