Evidence map›Paper›PMID 41398079›Full record

ArticleCommunications medicine2025

Alzheimer's disease plasma biomarkers are associated with cognitive performance among Hispanic/Latino adults.

Freddie Márquez, Wassim Tarraf, Sayaka Kuwayama, Deisha F Valencia, Ariana M Stickel, Richard B Lipton, Fernando D Testai, Natasha Z Anita, Kevin A Gonzalez, Robert Kaplan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Freddie MárquezDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA. frmarquez@ucsd.edu.ORCID http://orcid.org/0000-0001-9916-9225
Wassim TarrafInstitute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, MI, USA.
Sayaka KuwayamaDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Deisha F ValenciaDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Ariana M StickelDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Richard B LiptonDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-2652-2897
Fernando D TestaiDepartment of Neurology and Rehabilitation, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-7355-4915
Natasha Z AnitaDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0009-0007-9179-1539
Kevin A GonzalezDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Robert KaplanDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-2700-9593
Gregory A TalaveraDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Martha DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6791-8727
Jianwen CaiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-4945-6733
Haibo ZhouDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Douglas GalaskoDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6195-3241
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-3678-5888
Charles DeCarliDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.ORCID http://orcid.org/0000-0003-1914-2693
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6968-6985
Hector M GonzálezDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's BiomarkersK08AG075351 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariana Stickel · 2022 to 2026
$770k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS K08 AG075351NIA NIH HHS L30 AG074401NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG075758
6 · The paper itself

Abstract

backgroundBlood-based biomarkers hold promise as a minimally invasive tool for identifying early signs of Alzheimer's disease pathology and neurodegeneration. We investigated associations between plasma biomarkers of amyloid-beta, tau, neuroaxonal injury, and glial activation with cognitive performance among community-dwelling Hispanic/Latino adults in the United States.

methodsWe analyzed cross-sectional data from 5730 adults aged 50 years and older (unweighted; mean [SD], 63.5 [8.2] years) in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA; 2016-2018). Plasma concentrations of amyloid-beta (Aβ

resultsHere we show higher ln(pTau-181) and ln(NfL) are associated with lower global cognitive performance (b

conclusionsPlasma biomarkers related to Alzheimer's disease pathophysiology and broader neurodegenerative processes are associated with cognitive performance among Hispanic/Latino adults. These findings highlight the potential utility of blood-based biomarkers for identifying early cognitive vulnerability in this population.

Identifiers

PMID41398079
PMCPMC12815935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.