ArticleNature communications2025
Mitochondrial RNA cytosolic leakage drives the SASP.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nature reviews. Genetics · 2026Review
- Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.Biogerontology · 2026Review
- Mitochondrial homeodynamics in ageing: mechanisms, resilience, and interventions.Biogerontology · 2026Review
- Article
- Mitochondrial Dysfunction in Metabolic-Syndrome-Related MASLD/MASH: Metabolic Mechanisms and Therapeutic Perspectives.Metabolites · 2026Review
- Review
- Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits.Cell biochemistry and function · 2026Review
- Immunological consequences of senescence in physiology and pathology.Journal of translational medicine · 2026Review
- Nuclear-Mitochondria Crosstalk in Senescent Adipose-Derived Stem Cells.Smart medicine · 2026Review
- Interferon-alpha selectively signals mitochondrial pore opening to allow mitochondrial RNA release in systemic lupus erythematosus: pathophysiological implications.Cell communication and signaling : CCS · 2026Article
- Small but mighty: mitochondrial DNA at the centre of retrograde signalling.Cell communication and signaling : CCS · 2026Review
- Characterization of Mitochondrial Double-Stranded RNA Levels in Non-Small Cell Lung Carcinoma.Cancer research communications · 2026Article
- Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.Journal of nanobiotechnology · 2026Article
- The Sixth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Metformin inhibits nuclear egress of chromatin fragments in senescence and aging.Nature aging · 2026Article
- Redox-driven mitochondrial DNA stress in hepatocellular carcinoma: innate immune remodelling, tumour immune escape, and immunotherapy implications.Frontiers in immunology · 2026Review
- The role of mitochondrial DNA and RNA in promoting liver disease pathogenesis.Frontiers in cell and developmental biology · 2026Review
- Dyskerin dysfunction in cancer development: from telomere dysregulation to immune deficiency.American journal of cancer research · 2026Review
- Mitochondrial RNA in Inflammation.International journal of biological sciences · 2025Review
Corrections and comments
- Update of
Authors and funding
23 authors.
Stella Victorelli *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Victorelli.Stella@mayo.edu.ORCID http://orcid.org/0000-0001-5573-8019
Madeline Eppard *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Hélène MartiniDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8789-4585
Seung-Hwa WooDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9336-4457
Stacia P A EvertsDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0009-0004-2681-2768
Gung LeeDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-0223-7955
Nicholas PiriusDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Nuan HanDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4829-8876
Eugene Y LiangDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Ana Catarina FrancoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Yeaeun HanDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-1122-3691
Dominik SaulRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-0673-3710
Eva NóvoaDepartment of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
Rubén NogueirasDepartment of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-9976-9930
Patrick L SplinterDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Steven P O'HaraDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Olivia MorgenthalerDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-1217-0309
Lucía Valenzuela-PérezDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5145-303X
Hyun Se Kim LeeDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1104-4776
Diana JurkDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4486-0857
Nicholas F LaRussoDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3266-0831
Petra HirsovaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-0494-0924
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. passos.joao@mayo.edu.ORCID http://orcid.org/0000-0001-8765-1890
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla · 2019 to 2026
$28.7MPILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2MPathophysiology of Biliary DiseaseR01DK057993 · NIDDK · MAYO CLINIC ROCHESTER · PI LARUSSO, NICHOLAS F., O'HARA, STEVEN P · 2001 to 2025
$7.1MMSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7MPathobiology of Nonalcoholic SteatohepatitisR01DK130884 · NIDDK · MAYO CLINIC ROCHESTER · PI Petra Hirsova · 2021 to 2026
$2.5MThe role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2MDoes obesity exacerbate age-related cognitive decline via senescence?R01AG068182 · NIA · MAYO CLINIC ROCHESTER · PI JURK, DIANA · 2020 to 2024
$2.0MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUH3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.6MInvestigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and agingR01AG082708 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.5MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUG3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2021 to 2022
$1.1MFast super-resolution/confocal microscopy for GI cell biologyS10OD028633 · OD · MAYO CLINIC ROCHESTER · PI MC NIVEN, MARK A. · 2021 to 2021
$600kNCI NIH HHS UG3 CA268103NCI NIH HHS UH3 CA268103NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068182NIA NIH HHS R01 AG082708NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK057993NIDDK NIH HHS R01 DK130884NIGMS NIH HHS T32 GM145408NIH HHS S10 OD028633U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK084567
Abstract
Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (mtDNA) release and cGAS/STING pathway activation. Here, we demonstrate that mitochondrial RNA (mtRNA) also accumulates in the cytosol of senescent cells, activating RNA sensors RIG-I and MDA5, leading to MAVS aggregation and SASP induction. Inhibition of these RNA sensors significantly reduces SASP factors. Furthermore, BAX and BAK play a key role in mtRNA leakage during senescence, and their deletion diminishes SASP expression in vitro and in a mouse model of Metabolic Dysfunction-Associated Steatohepatitis (MASH). These findings highlight mtRNA's role in SASP regulation and its potential as a therapeutic target for mitigating age-related inflammation.
Indexed as
CytosolMitochondriaRNA, MitochondrialSenescence-Associated Secretory PhenotypeAdaptor Proteins, Signal TransducingAnimalsbcl-2-Associated X ProteinCellular SenescenceDEAD Box Protein 58DNA, MitochondrialHumansInterferon-Induced Helicase, IFIH1MaleMiceMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal Transducingbcl-2-Associated X ProteinDdx58 protein, mouseDEAD Box Protein 58DNA, MitochondrialIFIH1 protein, humanIfih1 protein, mouseInterferon-Induced Helicase, IFIH1MAVS protein, humanMAVS protein, mouseNucleotidyltransferasesReceptors, ImmunologicRIGI protein, humanRNA, Mitochondrial
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