Evidence map›Paper›PMID 41397955›Full record

ArticleCell death & disease2025

TRPV2 in muscle satellite cells is crucial for skeletal muscle remodelling.

Yanzhu Chen, Kimiaki Katanosaka, Makoto Shibuya, Yubing Dong, Lidan Zhang, Motoi Kanagawa, So-Ichiro Fukada, Keiji Naruse, Yuki Katanosaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [EstradiolZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanzhu ChenDepartment of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Kimiaki KatanosakaDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Makoto ShibuyaDepartment of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yubing DongDepartment of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Lidan ZhangLaboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka, Japan.ORCID http://orcid.org/0009-0008-0982-4934
Motoi KanagawaDepartment of Cell Biology and Molecular Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.ORCID http://orcid.org/0000-0003-0984-6398
So-Ichiro FukadaLaboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0003-4051-5108
Keiji NaruseDepartment of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yuki KatanosakaDepartment of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. katanosaka@kinjo-u.ac.jp.ORCID http://orcid.org/0000-0002-0250-4312

Funding

China Scholarship Council (CSC) 202108050035China Scholarship Council (CSC) 202108210109Japan Agency for Medical Research and Development (AMED) JP17gm5810003MEXT | Japan Society for the Promotion of Science (JSPS) 22562791MEXT | Japan Society for the Promotion of Science (JSPS) 23722538MEXT | Japan Society for the Promotion of Science (JSPS) 23722773MEXT | Japan Society for the Promotion of Science (JSPS) 23777371
6 · The paper itself

Abstract

Skeletal muscle remodelling relies on muscle stem cells (MuSCs) for regeneration after injury and hypertrophy in response to mechanical loading. However, the mechanisms that trigger MuSC activation and proliferation remain unclear. Transient receptor potential vanilloid 2 (TRPV2) ion channels respond to insulin-like growth factor-1 and mechanical stimuli to regulate the biological characteristics of various cells. Using a temporally inducible MuSC-specific conditional knockout (cKO) mouse, we show that TRPV2 regulates MuSC function and is essential for muscle remodelling. In cultured myofibre, MuSCs express TRPV2 and exhibit Ca

Indexed as

Muscle, SkeletalSatellite Cells, Skeletal MuscleTRPV Cation ChannelsAnimalsCalcium ChannelsCell ProliferationMiceMice, KnockoutMuscle DevelopmentMuscle Fibers, SkeletalPAX7 Transcription FactorRegenerationCalcium ChannelsPax7 protein, mousePAX7 Transcription FactorTrpv2 protein, mouseTRPV Cation Channels

Identifiers

PMID41397955
PMCPMC12706003

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.