Evidence map›Paper›PMID 41397873›Full record

ArticleLife science alliance2026

Structure and dynamics of 2x(CENP-A/H4)

Ahmad Ali-Ahmad, Mira Mors, Manuel Carrer, Xinmeng Li, Silvija Bilokapić, Mario Halić, Michele Cascella, Nikolina Sekulić

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmad Ali-AhmadNorwegian Centre for Molecular Biosciences and Medicine (NCMBM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway a.a.ahmad@ncmbm.uio.no.ORCID 0000-0002-9021-5405
Mira MorsDepartment of Chemistry, University of Oslo, Oslo, Norway.ORCID 0009-0002-9517-3432
Manuel CarrerDepartment of Chemistry, University of Oslo, Oslo, Norway.
Xinmeng LiDepartment of Chemistry, University of Oslo, Oslo, Norway.
Silvija BilokapićDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mario HalićDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Michele CascellaDepartment of Chemistry, University of Oslo, Oslo, Norway.ORCID 0000-0003-2266-5399
Nikolina SekulićNorwegian Centre for Molecular Biosciences and Medicine (NCMBM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo, Norway nikolina.sekulic@medisin.uio.no.ORCID 0000-0001-7555-3222

Funding

Structural and functional studies of chromatin modifiersR01GM135599 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HALIC, MARIO · 2020 to 2023
$1.5M
Chromatin of repetitive elementsR01GM141694 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HALIC, MARIO · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM135599NIGMS NIH HHS R01 GM141694
6 · The paper itself

Abstract

The centromere is a part of the chromosome that is essential for the even segregation of duplicated chromosomes during cell division. It is epigenetically defined by the presence of the histone H3 variant CENP-A. CENP-A associates specifically with a group of 16 proteins that form the constitutive centromere-associated network (CCAN) of proteins. In mitosis, the kinetochore forms on the CCAN to connect the duplicated chromosomes to the microtubules protruding from the cell poles. Previous studies have shown that CENP-A replaces H3 in nucleosomes, and recently, the structures of CENP-A-containing nucleosomes in complex with CCANs have been revealed, but they show only a limited interaction between CCANs and CENP-A. Here, we report the cryo-EM structure of 2x(CENP-A/H4)

Indexed as

CentromereCentromere Protein AChromatinHistonesChromosomal Proteins, Non-HistoneCryoelectron MicroscopyDNAHumansKinetochoresMitosisModels, MolecularNucleosomesCENPA protein, humanCentromere Protein AChromatinChromosomal Proteins, Non-HistoneDNAHistonesNucleosomes

Identifiers

PMID41397873
PMCPMC12705856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.